母体驱动的后代免疫教育

IF 7.5 2区 医学 Q1 IMMUNOLOGY
Krist Antunes Fernandes, Ai Ing Lim
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引用次数: 0

摘要

母体暴露于环境中,尤其是在妊娠期和哺乳期,会对后代的免疫系统发育和长期免疫力产生重大影响。哺乳动物的免疫系统是通过从子宫内开始到出生后的关键环境输入而发育的。这些关键的发育窗口对免疫系统的正常发育至关重要,而且一旦关闭,就可能无法重新打开。本综述将重点关注母体接触(尤其是病原体、饮食和微生物群)影响后代免疫力的机制。母体-后代免疫串扰的驱动机制包括母体抗体的转移、母体微生物组和微生物组衍生代谢物的变化以及免疫细胞和细胞因子通过胎盘和母乳喂养的转移。我们进一步讨论了孕期常见的短暂母体感染在向后代提供组织特异性免疫教育方面的作用。我们提出了 "母体驱动的免疫教育 "假说,认为后代可以利用在关键发育窗口期发生的母体接触来发展最佳的免疫能力,以抵御感染和炎症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Maternal-driven immune education in offspring

Maternal-driven immune education in offspring

Maternal environmental exposures, particularly during gestation and lactation, significantly influence the immunological development and long-term immunity of offspring. Mammalian immune systems develop through crucial inputs from the environment, beginning in utero and continuing after birth. These critical developmental windows are essential for proper immune system development and, once closed, may not be reopened. This review focuses on the mechanisms by which maternal exposures, particularly to pathogens, diet, and microbiota, impact offspring immunity. Mechanisms driving maternal-offspring immune crosstalk include transfer of maternal antibodies, changes in the maternal microbiome and microbiota-derived metabolites, and transfer of immune cells and cytokines via the placenta and breastfeeding. We further discuss the role of transient maternal infections, which are common during pregnancy, in providing tissue-specific immune education to offspring. We propose a “maternal-driven immune education” hypothesis, which suggests that offspring can use maternal encounters that occur during a critical developmental window to develop optimal immune fitness against infection and inflammation.

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来源期刊
Immunological Reviews
Immunological Reviews 医学-免疫学
CiteScore
16.20
自引率
1.10%
发文量
118
审稿时长
4-8 weeks
期刊介绍: Immunological Reviews is a specialized journal that focuses on various aspects of immunological research. It encompasses a wide range of topics, such as clinical immunology, experimental immunology, and investigations related to allergy and the immune system. The journal follows a unique approach where each volume is dedicated solely to a specific area of immunological research. However, collectively, these volumes aim to offer an extensive and up-to-date overview of the latest advancements in basic immunology and their practical implications in clinical settings.
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