抑郁症的免疫疗法:最新见解和未来目标

IF 12 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Ying Bai , Yang Cai , Di Chang , Daxing Li , Xinchen Huo , Tianhao Zhu
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引用次数: 0

摘要

抑郁症是导致全球残疾的一个重要因素,同时也增加了自杀的风险。大量证据表明,免疫失调可能在抑郁症的发病过程中起作用,并阻碍对抗抑郁治疗的反应。免疫失调可能会通过提高炎症反应导致易感人群患上抑郁症。在重度抑郁症患者的血液和脑脊液中可以观察到免疫细胞类型的差异和促炎介质的释放,这与神经免疫功能紊乱有关。因此,需要了解抑郁症中外周和中枢免疫靶点的相互作用。开发旨在调节免疫反应的创新疗法以治疗抑郁症刻不容缓。本综述阐述了抑郁症发病机制中涉及的免疫机制,评估了以免疫系统为靶点治疗抑郁症的潜力,并探讨了在抑郁症治疗中采用免疫疗法的优点和限制因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immunotherapy for depression: Recent insights and future targets

Depression stands as a prominent contributor to global disability, entailing an elevated risk of suicide. Substantial evidence supports the notion that immune dysregulation may play a role in the development of depression and impede responses to antidepressant treatments. Immune dysregulation may cause depression in susceptible individuals through raising inflammatory responses. Differences in immune cell types and the release of pro-inflammatory mediators are observed in the blood and cerebrospinal fluid of patients with major depressive disorder, which is associated with neuroimmune dysfunction. Therefore, the interaction of peripheral and central immune targets in depression needs to be understood. Urgent attention is required for the development of innovative therapeutics directed at modulating immune responses for the treatment of depression. This review delineates the immune mechanisms involved in the pathogenesis of depression, assesses the therapeutic potential of immune system targeting for depression treatment, and deliberates on the merits and constraints of employing immunotherapy in the management of depression.

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来源期刊
CiteScore
23.00
自引率
0.70%
发文量
222
审稿时长
90 days
期刊介绍: Pharmacology & Therapeutics, in its 20th year, delivers lucid, critical, and authoritative reviews on current pharmacological topics.Articles, commissioned by the editor, follow specific author instructions.This journal maintains its scientific excellence and ranks among the top 10 most cited journals in pharmacology.
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