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开发 BD1 选择性 BET 抑制剂的成功与挑战：专利回顾

IF 5.4 2区 医学 Q1 CHEMISTRY, MEDICINAL
Expert Opinion on Therapeutic Patents Pub Date : 2024-03-05 DOI:10.1080/13543776.2024.2327300
Monica Viviano, Alessandra Cipriano, Emanuele Fabbrizi, Alessandra Feoli, Sabrina Castellano, Gianluca Sbardella, Antonello Mai, Ciro Milite, Dante Rotili
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引用次数: 0

摘要

溴结构域和末端外（BET）结构域蛋白是一种转录辅因子，能识别组蛋白和非组蛋白的乙酰化赖氨酸，从而调节基因表达。BET 家族 ...
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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Successes and challenges in the development of BD1-selective BET inhibitors: a patent review
Bromodomain and ExtraTerminal (BET) domain proteins are transcriptional cofactors that, recognizing acetylated lysines of histone and non-histone proteins, can modulate gene expression. BET family ...
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来源期刊
Expert Opinion on Therapeutic Patents
Expert Opinion on Therapeutic Patents 医学-药学
CiteScore
12.10
自引率
1.50%
发文量
50
审稿时长
6-12 weeks
期刊介绍： Expert Opinion on Therapeutic Patents (ISSN 1354-3776 [print], 1744-7674 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles on recent pharmaceutical patent claims, providing expert opinion the scope for future development, in the context of the scientific literature. The Editors welcome: Reviews covering recent patent claims on compounds or applications with therapeutic potential, including biotherapeutics and small-molecule agents with specific molecular targets; and patenting trends in a particular therapeutic area Patent Evaluations examining the aims and chemical and biological claims of individual patents Perspectives on issues relating to intellectual property The audience consists of scientists, managers and decision-makers in the pharmaceutical industry and others closely involved in R&D Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days.
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