断奶反应期间 IgA 介导的宿主与微生物相互作用的控制影响肠道炎症。

IF 12.2 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Gut Microbes Pub Date : 2024-01-01 Epub Date: 2024-03-04 DOI:10.1080/19490976.2024.2323220
Wenjie Tang, Yusen Wei, Zhixiang Ni, Kangwei Hou, Xin M Luo, Haifeng Wang
{"title":"断奶反应期间 IgA 介导的宿主与微生物相互作用的控制影响肠道炎症。","authors":"Wenjie Tang, Yusen Wei, Zhixiang Ni, Kangwei Hou, Xin M Luo, Haifeng Wang","doi":"10.1080/19490976.2024.2323220","DOIUrl":null,"url":null,"abstract":"<p><p>The mechanisms of how host-microbe mutualistic relationships are established at weaning contingently upon B-cell surveillance remain inadequately elucidated. We found that <i>CD138</i><sup>+</sup> plasmacyte (PC)-mediated promotion of IgA response regulates the symbiosis between <i>Bacteroides uniformis</i> (<i>B. uniformis</i>) and the host during the weaning period. The IgA-skewed response of <i>CD138</i><sup>+</sup> PCs is essential for <i>B. uniformis</i> to occupy a defined gut luminal niche, thereby fostering stable colonization. Furthermore, <i>B. uniformis</i> within the natural gut niche was perturbed in the absence of IgA, resulting in exacerbated gut inflammation in IgA-deficient mice and weaned piglets. Thus, we propose that the priming and maintenance of intestinal IgA response from <i>CD138</i><sup>+</sup> PCs are required for host-microbial symbiosis, whereas the perturbation of which would enhance inflammation in weaning process.</p>","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":null,"pages":null},"PeriodicalIF":12.2000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10936605/pdf/","citationCount":"0","resultStr":"{\"title\":\"IgA-mediated control of host-microbial interaction during weaning reaction influences gut inflammation.\",\"authors\":\"Wenjie Tang, Yusen Wei, Zhixiang Ni, Kangwei Hou, Xin M Luo, Haifeng Wang\",\"doi\":\"10.1080/19490976.2024.2323220\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The mechanisms of how host-microbe mutualistic relationships are established at weaning contingently upon B-cell surveillance remain inadequately elucidated. We found that <i>CD138</i><sup>+</sup> plasmacyte (PC)-mediated promotion of IgA response regulates the symbiosis between <i>Bacteroides uniformis</i> (<i>B. uniformis</i>) and the host during the weaning period. The IgA-skewed response of <i>CD138</i><sup>+</sup> PCs is essential for <i>B. uniformis</i> to occupy a defined gut luminal niche, thereby fostering stable colonization. Furthermore, <i>B. uniformis</i> within the natural gut niche was perturbed in the absence of IgA, resulting in exacerbated gut inflammation in IgA-deficient mice and weaned piglets. Thus, we propose that the priming and maintenance of intestinal IgA response from <i>CD138</i><sup>+</sup> PCs are required for host-microbial symbiosis, whereas the perturbation of which would enhance inflammation in weaning process.</p>\",\"PeriodicalId\":12909,\"journal\":{\"name\":\"Gut Microbes\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":12.2000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10936605/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gut Microbes\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/19490976.2024.2323220\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/3/4 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gut Microbes","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/19490976.2024.2323220","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/3/4 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

在断奶时,宿主与微生物之间的共生关系是如何在B细胞监控下建立起来的,其机制仍未得到充分阐明。我们发现,CD138+质粒(PC)介导的 IgA 反应促进调节了断奶期均匀乳杆菌(B. uniformis)与宿主之间的共生关系。CD138+ PC 的 IgA 偏斜反应对于制服乳杆菌占据确定的肠腔生态位从而促进稳定定殖至关重要。此外,在缺乏 IgA 的情况下,B. uniformis 在自然肠道壁龛内的活动受到干扰,导致 IgA 缺乏的小鼠和断奶仔猪的肠道炎症加剧。因此,我们认为 CD138+ PCs 启动和维持肠道 IgA 反应是宿主-微生物共生所必需的,而干扰这种共生会加剧断奶过程中的炎症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
IgA-mediated control of host-microbial interaction during weaning reaction influences gut inflammation.

The mechanisms of how host-microbe mutualistic relationships are established at weaning contingently upon B-cell surveillance remain inadequately elucidated. We found that CD138+ plasmacyte (PC)-mediated promotion of IgA response regulates the symbiosis between Bacteroides uniformis (B. uniformis) and the host during the weaning period. The IgA-skewed response of CD138+ PCs is essential for B. uniformis to occupy a defined gut luminal niche, thereby fostering stable colonization. Furthermore, B. uniformis within the natural gut niche was perturbed in the absence of IgA, resulting in exacerbated gut inflammation in IgA-deficient mice and weaned piglets. Thus, we propose that the priming and maintenance of intestinal IgA response from CD138+ PCs are required for host-microbial symbiosis, whereas the perturbation of which would enhance inflammation in weaning process.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Gut Microbes
Gut Microbes Medicine-Microbiology (medical)
CiteScore
18.20
自引率
3.30%
发文量
196
审稿时长
10 weeks
期刊介绍: The intestinal microbiota plays a crucial role in human physiology, influencing various aspects of health and disease such as nutrition, obesity, brain function, allergic responses, immunity, inflammatory bowel disease, irritable bowel syndrome, cancer development, cardiac disease, liver disease, and more. Gut Microbes serves as a platform for showcasing and discussing state-of-the-art research related to the microorganisms present in the intestine. The journal emphasizes mechanistic and cause-and-effect studies. Additionally, it has a counterpart, Gut Microbes Reports, which places a greater focus on emerging topics and comparative and incremental studies.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信