星形胶质细胞大脑的代谢枢纽

IF 6.9 2区生物学 Q1 CELL BIOLOGY

Cold Spring Harbor perspectives in biology Pub Date : 2024-03-04 DOI:10.1101/cshperspect.a041355

L. Felipe Barros, Stefanie Schirmeier, Bruno Weber

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引用次数: 0

摘要

星形胶质细胞的新陈代谢占据了中心位置。星形胶质细胞介于神经元和血管之间，控制着神经元活动和可塑性所需的能量和构成物质的流动。它们也是局部解毒和废物回收的关键。神经元的新陈代谢是刚性的，而星形胶质细胞则可以根据局部需求和机体的营养状态在不同的新陈代谢模式之间切换。星形胶质细胞的新陈代谢状态甚至对外周营养物质的调动具有指导作用，并与信息处理和行为有关。在此，我们总结了最近在了解星形胶质细胞代谢及其对代谢平衡和认知的影响方面取得的进展。

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The Astrocyte: Metabolic Hub of the Brain

Astrocytic metabolism has taken center stage. Interposed between the neuron and the vasculature, astrocytes exert control over the fluxes of energy and building blocks required for neuronal activity and plasticity. They are also key to local detoxification and waste recycling. Whereas neurons are metabolically rigid, astrocytes can switch between different metabolic profiles according to local demand and the nutritional state of the organism. Their metabolic state even seems to be instructive for peripheral nutrient mobilization and has been implicated in information processing and behavior. Here, we summarize recent progress in our understanding of astrocytic metabolism and its effects on metabolic homeostasis and cognition.

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来源期刊

Cold Spring Harbor perspectives in biology CELL BIOLOGY-

CiteScore

15.00

自引率

1.40%

发文量

审稿时长

3-8 weeks

期刊介绍： Cold Spring Harbor Perspectives in Biology offers a comprehensive platform in the molecular life sciences, featuring reviews that span molecular, cell, and developmental biology, genetics, neuroscience, immunology, cancer biology, and molecular pathology. This online publication provides in-depth insights into various topics, making it a valuable resource for those engaged in diverse aspects of biological research.