基于唾液的小儿牙面炎症蛋白质分析。

IF 1.7 Q2 PEDIATRICS
Pediatric health, medicine and therapeutics Pub Date : 2024-02-27 eCollection Date: 2024-01-01 DOI:10.2147/PHMT.S440223
Bogusława Orzechowska-Wylęgała, Adam Wylęgała, Jolanta Zalejska Fiolka, Zenon Czuba, Michal Toborek
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引用次数: 0

摘要

目的:唾液中含有多种蛋白质,这些蛋白质对炎症过程的发展和预防非常重要。唾液研究的一个重要方面是口腔感染与炎症之间的关系,以及一些唾液蛋白的作用:证明哪些唾液细胞因子可作为儿童急性牙源性口腔和面部感染的生物标志物:研究包括两组患者:一组是由 28 名儿童组成的研究组:7 名女孩和 21 名男孩,年龄在 3-17 岁之间,患有急性颌面部炎症(DI);另一组是由 52 名儿童组成的对照组:16 名女孩和 36 名男孩,年龄在 4-17 岁之间,患有无并发症龋齿(CE)。研究人员比较了 DI 组和 CE 组儿童唾液中白细胞介素-5(IL-5)、白细胞介素-10(IL-10)、白细胞介素-17A(IL-17A)、白细胞介素-12p70(IL-12p70)、Eotaxin、Rantes、血管内皮生长因子(VEGF)和干扰素γ诱导蛋白 10(IP10)的水平。统计分析采用 Statistica 13 进行。采用学生 t 检验和 Wilcoxon 符号秩检验:结果表明,DI 组与 CE 组相比,IL-10、IL-17A 和 Eotaxin 在统计学上显著增加。IL-10 的显著性水平为 p=0.02,IL-17A 与 Eotaxin 相同,显著性水平为 p=0.04。其他测量参数在两组之间没有显著统计学差异:IL-10、IL-17A 和 Eotaxin 可作为儿童口腔和面部与牙齿相关的炎症状态的潜在生物标志物。这些生物标志物可用于识别和监测口腔和面部是否存在炎症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Saliva-Based Protein Analysis in Pediatric Dentofacial Inflammation.

Aim: Saliva contains various proteins that are important in developing inflammatory processes and their prevention. One key aspect of saliva research is the relationship between oral infections and inflammation, and the role of some salivary proteins.

The work aims: To demonstrate which salivary cytokines can be biomarkers of acute odontogenic oral and facial infections in children.

Material and methods: The study included two groups of patients: a study group of 28 children: 7 girls and 21 boys aged 3 -17 years with acute dentofacial inflammation (DI) and a control group of 52 children: 16 girls and 36 boys aged 4-17 years with uncomplicated dental caries (CE). The levels of Interleukin-5 (IL-5), Interleukin -10 (IL-10), Interleukin-17A (IL-17A), Interleukin-12p70 (IL-12p70), Eotaxin, Rantes, Vascular Endothelial Growth Factor (VEGF), and Interferon gamma-induced protein 10 (IP10) in the saliva of children in DI and CE groups were compared. Statistical analysis was performed with Statistica 13. The Student's t-test and the Wilcoxon signed-rank test were used.

Results: The results show that IL-10, IL-17A, and Eotaxin showed a statistically significant increase in the DI group compared to the CE group. The significance level for IL-10 was p=0.02, for IL-17A was equal to Eotaxin and p=0.04. The other measured parameters did not differ statistically significant between the two groups.

Conclusion: IL-10, IL-17A, and Eotaxin can be used as potential biomarkers for tooth-related inflammatory states of the oral cavity and face in children. These biomarkers can be useful in identifying and monitoring the presence of inflammation in the oral cavity and face.

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