比较不同运动对前列腺癌患者雄激素剥夺疗法不良反应的疗效：一项网络荟萃分析。

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY

Urologia Internationalis Pub Date : 2024-01-01 Epub Date: 2024-03-02 DOI:10.1159/000538114

Siping Hu, Xingyu Xiong, Shi Qiu, Jiakun Li, Hang Xu, Xianghong Zhou, Sheng Wang, Qiang Wei, Lu Yang

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引用次数: 0

摘要

简介以往的研究表明，运动对雄激素剥夺疗法（ADT）的不良反应有一定疗效。为了比较不同运动对 ADT 不良反应的疗效，我们进行了网络荟萃分析（NMA）：方法：我们在 PubMed、Embase 和 Cochrane 对照试验中央注册中心（CENTRAL）进行了文献检索。共纳入 19 项研究（1184 名参与者）。所有分析均在 R 4.1.2 或 RevMan 5.4.1 中进行：NMA结果显示，与对照组相比，有氧+阻力训练（ART）（MD = 5.92，95% CI [0.38；11.46]）和阻力运动（RE）（MD = 5.62，95% CI [2.70；8.55]）均能改善生活质量（QoL）。抗阻运动（P 得分：0.72）可能优于 RE（P 得分：0.7）。ART (MD = -10.89, 95% CI [-17.67; -4.11])能显著提高 400 米测试成绩。RE 能明显提高腿部力量（MD = 118，95% CI [78.75; 157.25]）和胸部力量（MD = 13.30 [4.07; 22.53]）。RE在腿部和胸部力量改善方面排名第一：结论：ART 对 QoL 有更好的疗效，并能显著提高 400 米测试成绩。RE在腿部和胸部力量方面可能更胜一筹。ART 可能适用于肌力下降不明显但同时伴有 ADT 其他不良反应（如心肺功能下降）的患者。

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Comparing Efficacies of Different Exercises on Androgen Deprivation Therapy Adverse Effects in Prostate Cancer Patients: A Network Meta-Analysis.

Introduction: Previous studies showed exercise have efficacies for androgen deprivation therapy (ADT) adverse effects. To compare the efficacies of different exercises on ADT adverse effects, we conducted the network meta-analysis (NMA).

Methods: Literature retrieval was performed in PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL). Nineteen studies (1,184 participants) were included. All analyses were performed in R 4.1.2 or RevMan 5.4.1.

Results: NMA results showed that compared with the control group, both aerobic + resistance training (ART) (MD = 5.92, 95% CI: 0.38; 11.46) and resistance exercise (RE) (MD = 5.62, 95% CI: 2.70; 8.55) improved quality of life (QoL). ART (P score: 0.72) may have superiority over RE (P score: 0.7). ART (MD = -10.89, 95% CI: -17.67; -4.11) significantly improved the performance of 400-m test. RE could significantly improve leg strength (MD = 118, 95% CI: 78.75; 157.25) and chest strength (MD = 13.30, 95% CI: 4.07; 22.53). RE ranked first for strength improvements of leg and chest.

Conclusion: ART showed better efficacy for the QoL and significantly improved the performance of 400-m test. RE might be superior for the strengths of leg and chest. ART may be appropriate for patients with less significant muscle strength decline but also other adverse effects of ADT, such as decreased cardiopulmonary function.

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来源期刊

Urologia Internationalis 医学-泌尿学与肾脏学

CiteScore

3.30

自引率

6.20%

发文量

审稿时长

3-8 weeks

期刊介绍： Concise but fully substantiated international reports of clinically oriented research into science and current management of urogenital disorders form the nucleus of original as well as basic research papers. These are supplemented by up-to-date reviews by international experts on the state-of-the-art of key topics of clinical urological practice. Essential topics receiving regular coverage include the introduction of new techniques and instrumentation as well as the evaluation of new functional tests and diagnostic methods. Special attention is given to advances in surgical techniques and clinical oncology. The regular publication of selected case reports represents the great variation in urological disease and illustrates treatment solutions in singular cases.