对超低体重新生儿早期口服初乳的短期效果:一项开放标签随机对照试验。

Q2 Medicine
Medical Journal of the Islamic Republic of Iran Pub Date : 2024-01-23 eCollection Date: 2024-01-01 DOI:10.47176/mjiri.38.7
Sedigheh Tehranchi, Farzaneh Palizban, Maryam Khoshnood Shariati, Naeeme Taslimi Taleghani, Arefeh Fayazi, Mohammad Farjami
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引用次数: 0

摘要

背景:口咽初乳(OCP)被认为是极低出生体重(VLBW)新生儿的一种潜在营养选择。本研究旨在确定早期口服初乳对极低出生体重新生儿的短期效果:这项开放标签随机对照试验针对 2022 年 2 月至 12 月期间在伊朗德黑兰马赫迪耶医院(Mahdieh Hospital)住院的 VLBW 新生儿。根据方案,所有符合条件的新生儿被平均随机分配到干预组(接受口服初乳(OC))和对照组(不接受 OC)。最后,采用独立样本 t 检验、卡方检验和费舍尔精确检验比较两组间早期服用 OC 的短期效果:在随机抽取的 80 名新生儿中,干预组和对照组分别有 37 名和 39 名新生儿进入最终分析。干预组和对照组的新生儿在外周插入中心导管(PICC)感染(P = 0.728)、败血症(P = 0.904)、坏死性小肠结肠炎(NEC)(P > 0.999)、脑室内出血(IVH)(P = 0.141)、早产儿视网膜病变(ROP)(P = 0.923)和支气管肺发育不良(BPD)(P = 0.633)。此外,在喂养量达到 120 cc/kg 的时间(P = 0.557)、达到出生体重的时间(P = 0.157)、住院时间(P = 0.532)和死亡率(P = 0.628)方面,各组之间没有明显差异:我们的研究结果表明,尽管早期服用 OC 是安全的,但并不能改善低体重儿的短期预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Short-Term Outcomes of Early Oral Colostrum Administration in VLBW Neonates: An Open-Label Randomized Controlled Trial.

Background: Oropharyngeal colostrum priming (OCP) has been proposed as a potential nutritional option for very low birth weight (VLBW) newborns. This study aimed to determine short-term outcomes of early oral colostrum administration in VLBW neonates.

Methods: This open-label randomized controlled trial was conducted on VLBW neonates admitted to Mahdieh Hospital, Tehran, Iran, between February and December 2022. According to the protocol, all eligible neonates were randomized evenly to the intervention group, which received oral colostrum (OC), and the control group, which received no OC. Finally, short-term outcomes of early OC administration were compared between groups using the independent-samples t test, chi-square, and Fisher exact tests.

Results: Of 80 randomized neonates, 37 and 39 from the intervention and control groups entered the final analysis, respectively. Neonates in the intervention and control groups did not significantly differ in terms of peripherally inserted central catheter (PICC) infection (P = 0.728), sepsis (P = 0.904), necrotizing enterocolitis (NEC) (P > 0.999), intraventricular hemorrhage (IVH) (P = 0.141), retinopathy of prematurity (ROP) (P = 0.923), and bronchopulmonary dysplasia (BPD) (P = 0.633). Furthermore, there was no significant difference between groups considering the time to reach 120 cc/kg feeds (P = 0.557), time to reach birth weight (P = 0.157), length of hospitalization (P = 0.532), and mortality rate (P = 0.628).

Conclusion: The results of our study revealed that despite safety, early OC administration did not improve any of the short-term outcomes in VLBW neonates.

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来源期刊
CiteScore
2.40
自引率
0.00%
发文量
90
审稿时长
8 weeks
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