使用质子泵抑制剂、过敏和哮喘之间的关系:2005-2006 年 NHANES 调查分析》。

IF 2.5 4区 医学 Q3 ALLERGY
International Archives of Allergy and Immunology Pub Date : 2024-01-01 Epub Date: 2024-03-01 DOI:10.1159/000535156
Ruili Yu, Xueyan Wang, Hongtian Wang, Xuechun Lu, Bo Yang
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引用次数: 0

摘要

导言:质子泵抑制剂(PPI)和组胺-2 受体拮抗剂等抑酸药物是治疗胃食管反流病和其他胃肠道疾病的常用处方药。然而,PPIs 的过度使用引发了对其潜在长期副作用的担忧。本研究旨在调查美国普通人群使用 PPI、过敏和哮喘之间的关系:方法:分析了 2005-2006 年美国国家健康与营养调查(NHANES)中年龄≥20 岁、有 PPI 使用信息以及过敏和哮喘问卷的人群的数据。通过单变量和多变量逻辑回归分析,确定使用 PPI、过敏症和哮喘之间的关联:共有 4,481 名参与者(加权后代表 198,543,007 名美国人)参与了分析。经调整后,在一般研究人群中,PPI 的使用与过敏或哮喘的存在无明显关联。然而,在未接触类固醇的女性中,与未使用 PPI 相比,使用 PPI 与过敏几率增加显著相关(调整后的几率比 [aOR] = 1.69,95% 置信区间 [CI]:1.002-2.86),其中使用埃索美拉唑与过敏几率增加显著相关(aOR = 2.68,95% CI:1.30-5.54),使用兰索拉唑与哮喘几率增加显著相关(aOR = 3.44,95% CI:1.50-7.87)。使用 PPI 的持续时间与过敏或哮喘没有明显关系:结论:在没有类固醇接触的美国妇女中,使用 PPI 与过敏和哮喘发病率增加有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations between Proton-Pump Inhibitor Usage, Allergy, and Asthma: An Analysis of NHANES 2005-2006.

Introduction: Acid suppression medications, such as proton-pump inhibitors (PPIs) and histamine-2 receptor antagonists, are commonly prescribed for the treatment of gastroesophageal reflux disease and other gastrointestinal disorders. However, concerns regarding potential long-term side effects are brought up by the overuse of PPIs. This study aimed to investigate the relationship between PPI usage, allergy, and asthma in the general US population.

Methods: Data of individuals aged ≥20 years who had information on PPI use and questionnaires on allergy and asthma in the US National Health and Nutrition Examination Survey (NHANES) 2005-2006 were analyzed. Univariate and multivariable logistic regression analyses were performed to determine the associations between PPI use, prevalent allergy, and asthma.

Results: A total of 4,481 participants (representing 198,543,007 US individuals after weighting) were included in the analyses. PPI use was not significantly associated with the presence of allergy or asthma in the general study population after adjustment. However, in females without steroid exposure, PPI use was significantly associated with increased odds of allergy (adjusted odds ratio [aOR] = 1.69, 95% confidence interval [CI]: 1.002-2.86), among which esomeprazole use was significantly associated with increased odds of allergy (aOR = 2.68, 95% CI: 1.30-5.54) and lansoprazole with increased odds of asthma (aOR = 3.44, 95% CI: 1.50-7.87) as compared to no PPI use. Duration of PPI use was not significantly associated with allergy or asthma.

Conclusions: In US women without steroid exposure, PPI use is associated with increased likelihood of prevalent allergy and asthma.

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来源期刊
CiteScore
5.60
自引率
3.60%
发文量
105
审稿时长
2 months
期刊介绍: ''International Archives of Allergy and Immunology'' provides a forum for basic and clinical research in modern molecular and cellular allergology and immunology. Appearing monthly, the journal publishes original work in the fields of allergy, immunopathology, immunogenetics, immunopharmacology, immunoendocrinology, tumor immunology, mucosal immunity, transplantation and immunology of infectious and connective tissue diseases.
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