利用 LC-MS/MS 建立同时估算大鼠血浆中奥硝唑和咪康唑含量的有效生物分析方法及其在药代动力学研究中的应用

IF 1 4区化学 Q4 BIOCHEMICAL RESEARCH METHODS

Journal of Liquid Chromatography & Related Technologies Pub Date : 2024-02-28 DOI:10.1080/10826076.2024.2320625

Subhradip Roychoudhury, Swadesh Kumar Pattanik, Rojalini Samanta, Ghanshyam Panigrahi, Swaha Satpathy, Mohsin Kazi, Muhammad Delwar Hussain, Arjun Patra, Kishanta Kumar Pradhan

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引用次数: 0

摘要

采用甲硝唑(Metronidazole, M...)和咪康唑(MCZ, M...)同时测定大鼠血浆中的奥硝唑(Onidazole, ODZ)和咪康唑(Miconazole, MCZ)。

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Development of a validated bioanalytical method for the simultaneous estimation of ornidazole and miconazole in rat plasma by LC-MS/MS and its application to a pharmacokinetic study

A highly sensitive, accurate, and robust LC-MS/MS method was developed and validated for the simultaneous determination of ornidazole (ODZ) and miconazole (MCZ) in rat plasma using metronidazole (M...

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来源期刊

Journal of Liquid Chromatography & Related Technologies 化学-分析化学

CiteScore

2.80

自引率

0.00%

发文量

审稿时长

4.9 months

期刊介绍： The Journal of Liquid Chromatography & Related Technologies is an internationally acclaimed forum for fast publication of critical, peer reviewed manuscripts dealing with analytical, preparative and process scale liquid chromatography and all of its related technologies, including TLC, capillary electrophoresis, capillary electrochromatography, supercritical fluid chromatography and extraction, field-flow technologies, affinity, and much more. New separation methodologies are added when they are developed. Papers dealing with research and development results, as well as critical reviews of important technologies, are published in the Journal.