恒电位流电化学的可扩展解决方案

IF 3.5 3区 化学 Q2 CHEMISTRY, APPLIED
Jeremy D. Griffin, Kaid C. Harper*, Simon Velasquez Morales, Westin H. Morrill, William I. Thornton, David Sutherland and Bradley A. Greiner, 
{"title":"恒电位流电化学的可扩展解决方案","authors":"Jeremy D. Griffin,&nbsp;Kaid C. Harper*,&nbsp;Simon Velasquez Morales,&nbsp;Westin H. Morrill,&nbsp;William I. Thornton,&nbsp;David Sutherland and Bradley A. Greiner,&nbsp;","doi":"10.1021/acs.oprd.3c00432","DOIUrl":null,"url":null,"abstract":"<p >The burgeoning interest in new electrochemical methods holds promise to provide a plethora of strategic disconnections for pharmaceutical compounds that are safer, less wasteful, and more streamlined than traditional chemical strategies. The use of organic electrochemistry in the commercial production of pharmaceuticals is exceedingly rare due to the lack of a modular infrastructure. Herein we describe the use of cascading continuous stirred tank reactors with individual cell potential control applied over reaction “stages” which demonstrate a balance between high selectivity and throughput necessary for electrochemistry to be a viable strategy in the pharmaceutical space. Using the high degree of control of cell potential afforded by this reactor design, a 1 kg demonstration was achieved in 9 h with high selectivity and yield (2.6 kg/day throughput).</p>","PeriodicalId":55,"journal":{"name":"Organic Process Research & Development","volume":"28 5","pages":"1877–1885"},"PeriodicalIF":3.5000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Scalable Solution to Constant-Potential Flow Electrochemistry\",\"authors\":\"Jeremy D. Griffin,&nbsp;Kaid C. Harper*,&nbsp;Simon Velasquez Morales,&nbsp;Westin H. Morrill,&nbsp;William I. Thornton,&nbsp;David Sutherland and Bradley A. Greiner,&nbsp;\",\"doi\":\"10.1021/acs.oprd.3c00432\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >The burgeoning interest in new electrochemical methods holds promise to provide a plethora of strategic disconnections for pharmaceutical compounds that are safer, less wasteful, and more streamlined than traditional chemical strategies. The use of organic electrochemistry in the commercial production of pharmaceuticals is exceedingly rare due to the lack of a modular infrastructure. Herein we describe the use of cascading continuous stirred tank reactors with individual cell potential control applied over reaction “stages” which demonstrate a balance between high selectivity and throughput necessary for electrochemistry to be a viable strategy in the pharmaceutical space. Using the high degree of control of cell potential afforded by this reactor design, a 1 kg demonstration was achieved in 9 h with high selectivity and yield (2.6 kg/day throughput).</p>\",\"PeriodicalId\":55,\"journal\":{\"name\":\"Organic Process Research & Development\",\"volume\":\"28 5\",\"pages\":\"1877–1885\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic Process Research & Development\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.oprd.3c00432\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Process Research & Development","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.oprd.3c00432","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0

摘要

人们对新型电化学方法的兴趣日渐浓厚,这种方法有望为药物化合物提供大量的战略断开方法,与传统的化学方法相比,这种方法更安全、浪费更少、流程更简化。由于缺乏模块化基础设施,有机电化学在药物商业生产中的应用极为罕见。在此,我们介绍了级联式连续搅拌罐反应器的使用情况,该反应器在反应 "阶段 "中应用了单个电池电位控制,展示了高选择性和高产能之间的平衡,而这正是电化学成为制药领域可行策略的必要条件。利用这种反应器设计提供的对电池电位的高度控制,在 9 小时内就完成了 1 公斤的演示,并获得了高选择性和高产率(2.6 公斤/天的产量)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A Scalable Solution to Constant-Potential Flow Electrochemistry

A Scalable Solution to Constant-Potential Flow Electrochemistry

A Scalable Solution to Constant-Potential Flow Electrochemistry

The burgeoning interest in new electrochemical methods holds promise to provide a plethora of strategic disconnections for pharmaceutical compounds that are safer, less wasteful, and more streamlined than traditional chemical strategies. The use of organic electrochemistry in the commercial production of pharmaceuticals is exceedingly rare due to the lack of a modular infrastructure. Herein we describe the use of cascading continuous stirred tank reactors with individual cell potential control applied over reaction “stages” which demonstrate a balance between high selectivity and throughput necessary for electrochemistry to be a viable strategy in the pharmaceutical space. Using the high degree of control of cell potential afforded by this reactor design, a 1 kg demonstration was achieved in 9 h with high selectivity and yield (2.6 kg/day throughput).

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
6.90
自引率
14.70%
发文量
251
审稿时长
2 months
期刊介绍: The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools,process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信