Bo Wang, Minjun Yan, Congyu Liu, Zhijun Yang, Xingchao Wang, Fu Zhao, Zhenmin Wang, Peng Li, Ying Wang, Shiwei Li, Gemingtian Liu, Pinan Liu
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引用次数: 0
摘要
背景介绍NF2-施万诺马特病（NF2）是一种常染色体显性遗传疾病，容易导致听力损失。听性脑干植入体（ABI）为NF2患者的听力康复提供了一种前景广阔的解决方案：综述有关 NF2 听力脑干植入术的现有文献，重点关注听力结果和听力脑干植入术相关并发症：系统综述遵循 PRISMA 指南，并在 PROSPERO 数据库（CRD42022362155）中注册。通过搜索 PubMed、EMBASE、CENTRAL、CMB 和 CNKI，确定了从开始到 2023 年 8 月的相关研究。提取了有关环境声音辨别、开放式辨别、封闭式辨别和 ABI 相关并发症的数据，并进行了荟萃分析。使用漏斗图和Egger检验评估发表偏倚：结果：共纳入 33 项研究。环境声辨别力的汇总估计值为 58%（95% CI 49-66%），封闭集辨别力的汇总估计值为 55%（95% CI 40-69%）。在开放式辨别力方面，仅声音辨别力的集合估计值为 30% (95% CI 19-42%)，仅唇语辨别力的集合估计值为 46% (95% CI 37-54%)，声音加唇语辨别力的集合估计值为 63% (95% CI 55-70%)。ABI 相关并发症的总发生率为 33% (95% CI 15-52%)：这项荟萃分析强调了ABI对NF2的有效性和安全性，为循证决策和听力康复策略提供了宝贵的见解。
Auditory brainstem implants for hearing rehabilitation in NF2-schwannomatosis: A systematic review and single-arm meta-analysis.
Background: NF2-schwannomatosis (NF2) is an autosomal dominant disorder prone to hearing loss. Auditory brainstem implants (ABIs) offer a promising solution for hearing rehabilitation in NF2.
Objective: To synthesize existing literature on ABI implantation in NF2, focusing on audiological outcomes and ABI-related complications.
Methods: The systematic review followed PRISMA guidelines and was registered in the PROSPERO database (CRD42022362155). Relevant studies were identified by searching PubMed, EMBASE, CENTRAL, CMB, and CNKI from inception to August 2023. Data on environmental sound discrimination, open-set discrimination, closed-set discrimination, and ABI-related complications were extracted and subjected to meta-analysis. Publication bias was evaluated using funnel plots and Egger's test.
Results: Thirty-three studies were included. The pooled estimate was 58% (95% CI 49-66%) for environmental sound discrimination and 55% (95% CI 40-69%) for closed-set discrimination. Regarding open-set discrimination, the pooled estimates were 30% (95% CI 19-42%) for sound only, 46% (95% CI 37-54%) for lip-reading only, and 63% (95% CI 55-70%) for sound plus lip-reading. The pooled occurrence of ABI-related complications was 33% (95% CI 15-52%).
Conclusion: This meta-analysis underscores the effectiveness and safety of ABIs in NF2, providing valuable insights for evidence-based decision-making and hearing rehabilitation strategies.
期刊介绍：
NeuroRehabilitation, an international, interdisciplinary, peer-reviewed journal, publishes manuscripts focused on scientifically based, practical information relevant to all aspects of neurologic rehabilitation. We publish unsolicited papers detailing original work/research that covers the full life span and range of neurological disabilities including stroke, spinal cord injury, traumatic brain injury, neuromuscular disease and other neurological disorders.
We also publish thematically organized issues that focus on specific clinical disorders, types of therapy and age groups. Proposals for thematic issues and suggestions for issue editors are welcomed.
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