新型 4H-chromene 类似物的设计、合成和抗菌评估

IF 1.8 3区 化学 Q3 CHEMISTRY, ORGANIC
Safaa S. M. Shaban , David S. A. Haneen , Mohsen M. Abou-El-Regal , Souad A. El-Metwally
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引用次数: 0

摘要

关于铬烯(苯并吡喃)核的重要药用和药理学事实促使我们专注于构建具有生物学价值的独特铬烯。新的苯并二氢吡喃衍生物2-15具有...
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Design, synthesis and antibacterial assessment of novel 4H-chromene analogues

The significant medicinal and pharmacological facts about chromenes (benzopyran) nucleus prompted us to focus on constructing unique chromenes with biological value. New chromene derivatives 2–15 were synthesized, and their antibacterial effectiveness was studied. The reaction of the 2-amino-4H-chromene derivative 1 with a variety of reagents such as acetic anhydride, formic acid, chloroacetyl chloride, cyclopentanone, ethyl acetoacetate, diethyl malonate, aldehydes, and isatin produced derivatives 213. Compound 1 was also treated with aromatic amines such as p-toluidine and/or benzene-1,4-diamine with formaldehyde, yielding derivatives 14 and 15, respectively; spectral techniques were used to confirm the predicted structures of all compounds. The antibacterial activity of the recently synthesized compounds was assessed against two types of bacteria, Bacillus subtilis and Escherichia coli. There is encouraging antibacterial activity in compounds 5 and 7.

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来源期刊
Synthetic Communications
Synthetic Communications 化学-有机化学
CiteScore
4.40
自引率
4.80%
发文量
156
审稿时长
4.3 months
期刊介绍: Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.
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