Safaa S. M. Shaban , David S. A. Haneen , Mohsen M. Abou-El-Regal , Souad A. El-Metwally
{"title":"新型 4H-chromene 类似物的设计、合成和抗菌评估","authors":"Safaa S. M. Shaban , David S. A. Haneen , Mohsen M. Abou-El-Regal , Souad A. El-Metwally","doi":"10.1080/00397911.2024.2324009","DOIUrl":null,"url":null,"abstract":"<div><p>The significant medicinal and pharmacological facts about chromenes (benzopyran) nucleus prompted us to focus on constructing unique chromenes with biological value. New chromene derivatives <strong>2–15</strong> were synthesized, and their antibacterial effectiveness was studied. The reaction of the 2-amino-4<em>H</em>-chromene derivative <strong>1</strong> with a variety of reagents such as acetic anhydride, formic acid, chloroacetyl chloride, cyclopentanone, ethyl acetoacetate, diethyl malonate, aldehydes, and isatin produced derivatives <strong>2</strong>–<strong>13</strong>. Compound <strong>1</strong> was also treated with aromatic amines such as <em>p</em>-toluidine and/or benzene-1,4-diamine with formaldehyde, yielding derivatives <strong>14</strong> and <strong>15</strong>, respectively; spectral techniques were used to confirm the predicted structures of all compounds. The antibacterial activity of the recently synthesized compounds was assessed against two types of bacteria, <em>Bacillus subtilis</em> and <em>Escherichia coli</em>. There is encouraging antibacterial activity in compounds <strong>5</strong> and <strong>7</strong>.</p></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Design, synthesis and antibacterial assessment of novel 4H-chromene analogues\",\"authors\":\"Safaa S. M. Shaban , David S. A. Haneen , Mohsen M. Abou-El-Regal , Souad A. El-Metwally\",\"doi\":\"10.1080/00397911.2024.2324009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The significant medicinal and pharmacological facts about chromenes (benzopyran) nucleus prompted us to focus on constructing unique chromenes with biological value. New chromene derivatives <strong>2–15</strong> were synthesized, and their antibacterial effectiveness was studied. The reaction of the 2-amino-4<em>H</em>-chromene derivative <strong>1</strong> with a variety of reagents such as acetic anhydride, formic acid, chloroacetyl chloride, cyclopentanone, ethyl acetoacetate, diethyl malonate, aldehydes, and isatin produced derivatives <strong>2</strong>–<strong>13</strong>. Compound <strong>1</strong> was also treated with aromatic amines such as <em>p</em>-toluidine and/or benzene-1,4-diamine with formaldehyde, yielding derivatives <strong>14</strong> and <strong>15</strong>, respectively; spectral techniques were used to confirm the predicted structures of all compounds. The antibacterial activity of the recently synthesized compounds was assessed against two types of bacteria, <em>Bacillus subtilis</em> and <em>Escherichia coli</em>. There is encouraging antibacterial activity in compounds <strong>5</strong> and <strong>7</strong>.</p></div>\",\"PeriodicalId\":22119,\"journal\":{\"name\":\"Synthetic Communications\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-02-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Synthetic Communications\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S0039791124000158\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synthetic Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S0039791124000158","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Design, synthesis and antibacterial assessment of novel 4H-chromene analogues
The significant medicinal and pharmacological facts about chromenes (benzopyran) nucleus prompted us to focus on constructing unique chromenes with biological value. New chromene derivatives 2–15 were synthesized, and their antibacterial effectiveness was studied. The reaction of the 2-amino-4H-chromene derivative 1 with a variety of reagents such as acetic anhydride, formic acid, chloroacetyl chloride, cyclopentanone, ethyl acetoacetate, diethyl malonate, aldehydes, and isatin produced derivatives 2–13. Compound 1 was also treated with aromatic amines such as p-toluidine and/or benzene-1,4-diamine with formaldehyde, yielding derivatives 14 and 15, respectively; spectral techniques were used to confirm the predicted structures of all compounds. The antibacterial activity of the recently synthesized compounds was assessed against two types of bacteria, Bacillus subtilis and Escherichia coli. There is encouraging antibacterial activity in compounds 5 and 7.
期刊介绍:
Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.