预先存在的抗体允许新的 B 细胞在 "召回 "生殖中心成熟

IF 67.7 1区医学 Q1 IMMUNOLOGY

Nature Reviews Immunology Pub Date : 2024-03-01 DOI:10.1038/s41577-024-01012-w

Jake Herb, Maria Curotto de Lafaille

引用次数: 0

摘要

再次接触以前遇到过的抗原会导致强大的抗体反应，并形成 "召回 "生殖中心。Schiepers等人的一篇预发表论文显示，这些生殖中心的抗体反馈确保了能够靶向逃逸表位的幼稚B细胞的成熟。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Pre-existing antibody allows for maturation of new B cells in ‘recall’ germinal centres

Re-exposure to a previously encountered antigen leads to robust antibody responses and the formation of ‘recall’ germinal centres. A preprint by Schiepers et al. shows that antibody feedback in these germinal centres ensures the maturation of naive B cells that can target escape epitopes.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nature Reviews Immunology 医学-免疫学

CiteScore

93.40

自引率

0.40%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.