成骨细胞衍生的 ATP 可维持骨髓浆细胞。

IF 67.7 1区医学 Q1 IMMUNOLOGY

Nature Reviews Immunology Pub Date : 2024-02-29 DOI:10.1038/s41577-024-01015-7

Yvonne Bordon

引用次数: 0

摘要

浆细胞利用 P2RX4 来感知成骨细胞调节 ATP 的释放，从而防止 ER 应激导致的细胞凋亡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Osteoblast-derived ATP maintains bone marrow plasma cells

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Osteoblast-derived ATP maintains bone marrow plasma cells

Plasma cells use P2RX4 to sense the regulated release of ATP from osteoblasts and this protects against ER stress-driven apoptosis.

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来源期刊

Nature Reviews Immunology 医学-免疫学

CiteScore

93.40

自引率

0.40%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.