发育过程中的雌激素信号传导:斑马鱼的最新研究成果。

Hannah M Wesselman, Rebecca A Wingert
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引用次数: 0

摘要

虽然雌激素在传统上被认为是一种性激素,但它对生殖系统以外的组织发育也有很大影响。雌激素合成酶和雌激素受体在脊椎动物组织中广泛表达,进一步表明了它们在各种过程中的重要性。其中包括斑马鱼的组织,斑马鱼是研究早期发育的一个特别合适的模型,因为斑马鱼在子宫外发育迅速,其基因和细胞组成与其他脊椎动物一致。在这篇综述中,我们将为读者介绍雌激素信号传导的概况,讨论斑马鱼动物模型的重要特性,特别关注肾脏,并探讨斑马鱼研究中关于雌激素信号传导在从肾脏到大脑和肝脏等胚层衍生物的器官发生中的作用的最新见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Estrogen signaling in development: recent insights from the zebrafish.

While traditionally recognized as a sex hormone, estrogen has a potent effect on the development of tissues beyond those of the reproductive system. Estrogen synthesis enzymes and estrogen receptors are broadly expressed in vertebrate tissues, further indicating their importance in various processes. These include the tissues of the zebrafish, which is a particularly suitable model for studying early development due to its rapid ex utero ontogeny and conserved genetic and cellular composition with other vertebrates. In this review, we provide readers with an overview of estrogen signaling, discuss important attributes of the zebrafish animal model with a special focus on the kidney, and explore recent insights from zebrafish studies about the roles of estrogen signaling in organogenesis across germ layer derivatives that range from the kidney to the brain and liver.

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