线粒体在脂质处理和胃肠道疾病中的功能障碍。

IF 11.4 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Trends in Endocrinology and Metabolism Pub Date : 2024-05-01 Epub Date: 2024-02-27 DOI:10.1016/j.tem.2024.02.009

Yan Hu, Hao Huang, Rong Xiang

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引用次数: 0

摘要

线粒体功能障碍主要导致肌肉萎缩和神经变性的脑肌病。然而，它们对其他组织，尤其是胃肠道的影响还需要进一步研究。最近，Moschandrea 等人在《自然》杂志上发表了一篇报告，他们利用线粒体氨基酰-tRNA 合成酶 DARS2 缺陷的小鼠研究了肠细胞线粒体在膳食脂质加工和运输中的作用。他们的研究揭示了线粒体功能障碍导致胃肠功能紊乱的原因。

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Mitochondrial dysfunction in lipid processing and gastrointestinal disorders.

Mitochondrial dysfunctions predominantly cause encephalomyopathies with muscle atrophy and neurodegeneration. However, their impact on other tissues, particularly the gastrointestinal tract, requires further investigation. In a recent report in Nature, Moschandrea et al. used mice deficient in the mitochondrial aminoacyl-tRNA synthetase DARS2 to investigate the role of enterocytic mitochondria in dietary lipid processing and transport. Their work sheds light on the development of gastrointestinal disorders as a result of mitochondrial dysfunction.

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来源期刊

Trends in Endocrinology and Metabolism 医学-内分泌学与代谢

CiteScore

20.10

自引率

0.00%

发文量

审稿时长

82 days

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