靶向 TDO2 治疗肺腺癌的潜力

IF 3.6 2区生物学 Q1 BIOCHEMICAL RESEARCH METHODS

Journal of Proteome Research Pub Date : 2024-02-29 DOI:10.1021/acs.jproteome.3c00746

Er Jin, Zhidong Yin, Xiuxiu Zheng, Chenhong Yan, Kai Xu, Fouejio Yemele Eunice and Yue Gao*,

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引用次数: 0

摘要

色氨酸分解代谢在癌细胞的代谢重组中发挥着重要作用，以支持肿瘤发生和发展的特殊需求。色氨酸途径的分解产物犬尿氨酸具有抑制肿瘤细胞免疫反应的能力。在这项研究中，我们进行了内部和外部队列研究，以揭示色氨酸 2,3-二氧化酶（TDO）对肺腺癌（LUAD）的重要性。我们的研究进一步证明，TDO2的表达与LUAD细胞的增殖、存活和侵袭有关，针对LUAD肿瘤的TDO2可能是一种潜在的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Potential of Targeting TDO2 as the Lung Adenocarcinoma Treatment

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Potential of Targeting TDO2 as the Lung Adenocarcinoma Treatment

Tryptophan catabolism plays an important role in the metabolic reconnection in cancer cells to support special demands of tumor initiation and progression. The catabolic product of the tryptophan pathway, kynurenine, has the capability of suppressing the immune reactions of tumor cells. In this study, we conducted internal and external cohort studies to reveal the importance of tryptophan 2,3-dioxygenase (TDO) for lung adenocarcinoma (LUAD). Our study further demonstrated that the TDO2 expression was associated with the proliferation, survival, and invasion of LUAD cells, and targeting TDO2 for LUAD tumors could be a potential therapeutic strategy.

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来源期刊

Journal of Proteome Research 生物-生化研究方法

CiteScore

9.00

自引率

4.50%

发文量

251

审稿时长

3 months

期刊介绍： Journal of Proteome Research publishes content encompassing all aspects of global protein analysis and function, including the dynamic aspects of genomics, spatio-temporal proteomics, metabonomics and metabolomics, clinical and agricultural proteomics, as well as advances in methodology including bioinformatics. The theme and emphasis is on a multidisciplinary approach to the life sciences through the synergy between the different types of "omics".