{"title":"根据新制定的欧盟法规，使用 LC-ORBITRAP-MS 检测某些动物源性食品中的全氟物质 (PFAS)","authors":"Elina Pasecnaja, Dzintars Zacs","doi":"10.1007/s12161-024-02603-y","DOIUrl":null,"url":null,"abstract":"<div><p>Per- and polyfluorinated alkyl substances (PFASs) are compounds which exhibit unique chemical and physical properties resulting in bioaccumulation in aquatic and terrestrial food chains. Due to a global concern on the adverse health effects, European Food Safety Authority (EFSA) set tolerable weekly intake and thereafter, to ensure an efficient protection of public health, the European Commission set maximum levels for four priority components, namely perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorohexanesulfonic acid (PFHxS), and perfluorooctanesulfonic acid (PFOS), in certain foodstuffs. This study demonstrates an analytical method based on high-performance liquid chromatography (HPLC) coupled to Orbitrap mass spectrometry (Orbitrap-MS) for the quantitative determination of four priority PFASs. The optimized and validated LC-Orbitrap-MS method fulfils the requirements specified in the “Guidance Document on Analytical Parameters for the Determination of Per- and Polyfluoroalkyl Substances (PFASs) in Food and Feed” and allows a reliable analysis of PFASs in selected food products, fulfilling the requirements of Commission Regulation 915/2023, Commission Regulation (EU) 2022/1428, and Commission Recommendation (EU) 2022/1431. The method was successfully used for the compliance testing of four priority PFASs according to the newly established legislation in food samples (<i>n = 58</i>) represented by eggs, fish, meat, and meat by-products collected in Latvia, providing the occurrence data from the Baltic states.</p></div>","PeriodicalId":561,"journal":{"name":"Food Analytical Methods","volume":"17 4","pages":"640 - 649"},"PeriodicalIF":2.6000,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Determination of Perfluorinated Substances (PFAS) Using LC-ORBITRAP-MS in Certain foodstuffs of Animal Origin According to newly established EU legislation\",\"authors\":\"Elina Pasecnaja, Dzintars Zacs\",\"doi\":\"10.1007/s12161-024-02603-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Per- and polyfluorinated alkyl substances (PFASs) are compounds which exhibit unique chemical and physical properties resulting in bioaccumulation in aquatic and terrestrial food chains. Due to a global concern on the adverse health effects, European Food Safety Authority (EFSA) set tolerable weekly intake and thereafter, to ensure an efficient protection of public health, the European Commission set maximum levels for four priority components, namely perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorohexanesulfonic acid (PFHxS), and perfluorooctanesulfonic acid (PFOS), in certain foodstuffs. This study demonstrates an analytical method based on high-performance liquid chromatography (HPLC) coupled to Orbitrap mass spectrometry (Orbitrap-MS) for the quantitative determination of four priority PFASs. The optimized and validated LC-Orbitrap-MS method fulfils the requirements specified in the “Guidance Document on Analytical Parameters for the Determination of Per- and Polyfluoroalkyl Substances (PFASs) in Food and Feed” and allows a reliable analysis of PFASs in selected food products, fulfilling the requirements of Commission Regulation 915/2023, Commission Regulation (EU) 2022/1428, and Commission Recommendation (EU) 2022/1431. The method was successfully used for the compliance testing of four priority PFASs according to the newly established legislation in food samples (<i>n = 58</i>) represented by eggs, fish, meat, and meat by-products collected in Latvia, providing the occurrence data from the Baltic states.</p></div>\",\"PeriodicalId\":561,\"journal\":{\"name\":\"Food Analytical Methods\",\"volume\":\"17 4\",\"pages\":\"640 - 649\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-02-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food Analytical Methods\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s12161-024-02603-y\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Analytical Methods","FirstCategoryId":"97","ListUrlMain":"https://link.springer.com/article/10.1007/s12161-024-02603-y","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Determination of Perfluorinated Substances (PFAS) Using LC-ORBITRAP-MS in Certain foodstuffs of Animal Origin According to newly established EU legislation
Per- and polyfluorinated alkyl substances (PFASs) are compounds which exhibit unique chemical and physical properties resulting in bioaccumulation in aquatic and terrestrial food chains. Due to a global concern on the adverse health effects, European Food Safety Authority (EFSA) set tolerable weekly intake and thereafter, to ensure an efficient protection of public health, the European Commission set maximum levels for four priority components, namely perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorohexanesulfonic acid (PFHxS), and perfluorooctanesulfonic acid (PFOS), in certain foodstuffs. This study demonstrates an analytical method based on high-performance liquid chromatography (HPLC) coupled to Orbitrap mass spectrometry (Orbitrap-MS) for the quantitative determination of four priority PFASs. The optimized and validated LC-Orbitrap-MS method fulfils the requirements specified in the “Guidance Document on Analytical Parameters for the Determination of Per- and Polyfluoroalkyl Substances (PFASs) in Food and Feed” and allows a reliable analysis of PFASs in selected food products, fulfilling the requirements of Commission Regulation 915/2023, Commission Regulation (EU) 2022/1428, and Commission Recommendation (EU) 2022/1431. The method was successfully used for the compliance testing of four priority PFASs according to the newly established legislation in food samples (n = 58) represented by eggs, fish, meat, and meat by-products collected in Latvia, providing the occurrence data from the Baltic states.
期刊介绍：
Food Analytical Methods publishes original articles, review articles, and notes on novel and/or state-of-the-art analytical methods or issues to be solved, as well as significant improvements or interesting applications to existing methods. These include analytical technology and methodology for food microbial contaminants, food chemistry and toxicology, food quality, food authenticity and food traceability. The journal covers fundamental and specific aspects of the development, optimization, and practical implementation in routine laboratories, and validation of food analytical methods for the monitoring of food safety and quality.
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