Xiaoyan He, Shuo Ma, Nan Sun, Miaomiao Hou, Zheping Tan, Runze Cao
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Hierarchical TiO2–Ag/hydrogel coating used for outstanding antifouling detection of serotonin
Serotonin (5-HT) is an important neurotransmitter in vivo, regulating almost all human behavior and cognitive processes. Antifouling surface that can prevent undesirable adhesion is a key factor in the detection of 5-HT, hydrogels are considered as excellent candidates for non-fouling materials. It still remains a challenge to fabricate antifouling composites on electrode that can combine the properties of the hydrogels and surface morphology characteristics, at the same time, keeping good conductivity of the electrode. Herein, we report a new antifouling electrochemical biosensor for 5-HT detection. Using the photocatalytic activity of TiO2 and the conductivity of Ag nanoparticles, the antifouling layer of P(VPA-SBMA-GMA) hydrogel was formed by in situ polymerization on the surface of hierarchical nanoscale TiO2–Ag nanocomposite, 5-HT aptamers were further bound on the surface of the hydrogel for specific recognition. With these advantages, the constructed sensor had a wide detection range (0.5 pM–100 nM) and a lower detection limit (5 fM) for 5-HT.
Graphical abstract
Manufacturing process, material characterization and effect DPV diagram of a new electrochemical aptamer sensor.
期刊介绍：
Original research on all aspects of polymer science, engineering and technology, including nanotechnology
Presents original research articles on all aspects of polymer science, engineering and technology
Coverage extends to such topics as nanotechnology, biotechnology and information technology
The English-language journal of the Polymer Society of Korea
Macromolecular Research is a scientific journal published monthly by the Polymer Society of Korea. Macromolecular Research publishes original researches on all aspects of polymer science, engineering, and technology as well as new emerging technologies using polymeric materials including nanotechnology, biotechnology, and information technology in forms of Articles, Communications, Notes, Reviews, and Feature articles.
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