消除致病性自身抗体分泌细胞的 CAAR NK 细胞方法

IF 28.6 1区 医学 Q1 UROLOGY & NEPHROLOGY
Ellen F. Carney
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引用次数: 0

摘要

自身抗体与荚膜细胞上表达的自身抗原结合会导致膜性肾病。新的研究结果表明,嵌合型自身抗体受体(CAAR)自然杀伤(NK)细胞可用于消除这种疾病中产生自身抗体的致病细胞。研究人员总结说,CAAR NK和T细胞能以抗原特异性的方式消除分泌抗体的靶细胞,证明了这种策略作为治疗方法的可行性。研究人员认为,与使用更传统的自体嵌合抗原受体T细胞疗法相比,使用他们的CAAR NK细胞疗法可以实现现成的高特异性、低不良反应治疗,并减少长期并发症、患者负担和治疗费用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A CAAR NK cell approach to eliminate pathogenic autoantibody-secreting cells

A CAAR NK cell approach to eliminate pathogenic autoantibody-secreting cells
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来源期刊
Nature Reviews Nephrology
Nature Reviews Nephrology 医学-泌尿学与肾脏学
CiteScore
39.00
自引率
1.20%
发文量
127
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Nephrology aims to be the premier source of reviews and commentaries for the scientific communities it serves. It strives to publish authoritative, accessible articles. Articles are enhanced with clearly understandable figures, tables, and other display items. Nature Reviews Nephrology publishes Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements. The content is relevant to nephrologists and basic science researchers. The broad scope of the journal ensures that the work reaches the widest possible audience.
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