半胱氨酸过硫化物在肿瘤生物学中的多种作用

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Nano Materials Pub Date : 2024-02-28 DOI:10.1016/j.cbpa.2024.102440

Klaudia Borbényi-Galambos , Ágnes Czikora , Katalin Erdélyi , Péter Nagy

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引用次数: 0

摘要

重新连接转硫化途径被认为是癌细胞对环境条件的一种快速适应性代谢反应，以支持其对半胱氨酸需求的增加，并产生包括硫化氢（H2S）和半胱氨酸过硫化物在内的活性硫物种（RSS）。这可以直接（通过 RSS）或间接（通过提供 Cys）触发关键蛋白质半胱氨酸残基的化学或酶催化过硫化反应，以保护它们免受氧化损伤并协调蛋白质功能，从而促进癌细胞的可塑性。本综述重点介绍了过硫化物介导的生物过程的主要方面，并结合癌细胞存活、生物能、增殖、肿瘤血管生成、对缺氧和氧化应激的适应以及上皮到间质转化的调控等方面进行了深入探讨。

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Versatile roles of cysteine persulfides in tumor biology

Rewiring the transsulfuration pathway is recognized as a rapid adaptive metabolic response to environmental conditions in cancer cells to support their increased cysteine demand and to produce Reactive Sulfur Species (RSS) including hydrogen sulfide (H₂S) and cysteine persulfide. This can directly (via RSS) or indirectly (by supplying Cys) trigger chemical or enzyme catalyzed persulfidation on critical protein cysteine residues to protect them from oxidative damage and to orchestrate protein functions, and thereby contribute to cancer cell plasticity. In this review key aspects of persulfide-mediated biological processes are highlighted and critically discussed in relation to cancer cell survival, bioenergetics, proliferation as well as in tumor angiogenesis, adaptation to hypoxia and oxidative stress, and regulation of epithelial to mesenchymal transition.

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.