Alexa Acevedo , Kirk A. Muñoz , Molly Stec , Kathryn Pitt , Sarah A. Jones , Jane M. Manfredi
{"title":"术前服用昂丹司琼对接受腹腔镜胃切除术和阉割术的健康犬术后恶心的影响","authors":"Alexa Acevedo , Kirk A. Muñoz , Molly Stec , Kathryn Pitt , Sarah A. Jones , Jane M. Manfredi","doi":"10.1016/j.vaa.2024.01.004","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To investigate if preoperative ondansetron reduces postoperative nausea associated with laparoscopic gastropexy and castration in dogs.</p></div><div><h3>Study design</h3><p>Prospective clinical study.</p></div><div><h3>Animals</h3><p>Twenty client-owned, healthy male dogs.</p></div><div><h3>Methods</h3><p>Dogs were premedicated with dexmedetomidine (2–5 mcg kg<sup>–1</sup>) and methadone (0.2–0.5 mg kg<sup>–1</sup>) intramuscularly. General anesthesia was induced with propofol and maintained with an inhalant anesthetic agent. Dogs were randomized into group S (saline 0.1 mL kg<sup>–1</sup>, intravenously) or group O (ondansetron 0.2 mg kg<sup>–1</sup>, intravenously). Plasma and serum were collected before premedication and 3 hours postextubation to measure arginine vasopressin (AVP) and cortisol concentrations. Nausea scoring occurred before and 10 minutes after premedication, immediately after extubation, and at 1, 2 and 3 hours postextubation. Data were analyzed by mixed and split-plot <span>anova</span> with Bonferroni adjustment for the number of group comparisons. Significance was set at <em>p</em> < 0.05.</p></div><div><h3>Results</h3><p>Nausea scores increased over time at 1 (<em>p</em> = 0.01) and 2 (<em>p</em> < 0.001) hours postextubation in both groups compared with before premedication. Median nausea score (0–100 mm) for groups S and O before premedication were 2.5 and 0.5 mm, respectively. At 1 and 2 hours postextubation, group S scored 7.5 and 4.0 mm and group O scored 6.0 and 5.0 mm, respectively. No significant differences in nausea scores within or between groups were observed before premedication and 3 hours postextubation. Cortisol concentrations increased significantly 3 hours postextubation in both groups (<em>p</em> < 0.001) compared with before premedication, with no differences between groups. AVP concentrations showed no significant differences within or between groups.</p></div><div><h3>Conclusions and clinical relevance</h3><p>Preoperative intravenous administration of ondansetron (0.2 mg kg<sup>–1</sup>) did not impact postoperative nausea after laparoscopic gastropexy and castration. Investigation of higher doses of ondansetron on the incidence of postoperative nausea and vomiting in dogs after surgery is warranted.</p></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1467298724000047/pdfft?md5=2dc7b85af1abfee601407cf8d596f8c6&pid=1-s2.0-S1467298724000047-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Effect of preoperative ondansetron on postoperative nausea in healthy dogs undergoing laparoscopic gastropexy and castration\",\"authors\":\"Alexa Acevedo , Kirk A. Muñoz , Molly Stec , Kathryn Pitt , Sarah A. Jones , Jane M. Manfredi\",\"doi\":\"10.1016/j.vaa.2024.01.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To investigate if preoperative ondansetron reduces postoperative nausea associated with laparoscopic gastropexy and castration in dogs.</p></div><div><h3>Study design</h3><p>Prospective clinical study.</p></div><div><h3>Animals</h3><p>Twenty client-owned, healthy male dogs.</p></div><div><h3>Methods</h3><p>Dogs were premedicated with dexmedetomidine (2–5 mcg kg<sup>–1</sup>) and methadone (0.2–0.5 mg kg<sup>–1</sup>) intramuscularly. General anesthesia was induced with propofol and maintained with an inhalant anesthetic agent. Dogs were randomized into group S (saline 0.1 mL kg<sup>–1</sup>, intravenously) or group O (ondansetron 0.2 mg kg<sup>–1</sup>, intravenously). Plasma and serum were collected before premedication and 3 hours postextubation to measure arginine vasopressin (AVP) and cortisol concentrations. Nausea scoring occurred before and 10 minutes after premedication, immediately after extubation, and at 1, 2 and 3 hours postextubation. Data were analyzed by mixed and split-plot <span>anova</span> with Bonferroni adjustment for the number of group comparisons. Significance was set at <em>p</em> < 0.05.</p></div><div><h3>Results</h3><p>Nausea scores increased over time at 1 (<em>p</em> = 0.01) and 2 (<em>p</em> < 0.001) hours postextubation in both groups compared with before premedication. Median nausea score (0–100 mm) for groups S and O before premedication were 2.5 and 0.5 mm, respectively. At 1 and 2 hours postextubation, group S scored 7.5 and 4.0 mm and group O scored 6.0 and 5.0 mm, respectively. No significant differences in nausea scores within or between groups were observed before premedication and 3 hours postextubation. Cortisol concentrations increased significantly 3 hours postextubation in both groups (<em>p</em> < 0.001) compared with before premedication, with no differences between groups. AVP concentrations showed no significant differences within or between groups.</p></div><div><h3>Conclusions and clinical relevance</h3><p>Preoperative intravenous administration of ondansetron (0.2 mg kg<sup>–1</sup>) did not impact postoperative nausea after laparoscopic gastropexy and castration. Investigation of higher doses of ondansetron on the incidence of postoperative nausea and vomiting in dogs after surgery is warranted.</p></div>\",\"PeriodicalId\":23626,\"journal\":{\"name\":\"Veterinary anaesthesia and analgesia\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1467298724000047/pdfft?md5=2dc7b85af1abfee601407cf8d596f8c6&pid=1-s2.0-S1467298724000047-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Veterinary anaesthesia and analgesia\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1467298724000047\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary anaesthesia and analgesia","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1467298724000047","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Effect of preoperative ondansetron on postoperative nausea in healthy dogs undergoing laparoscopic gastropexy and castration
Objective
To investigate if preoperative ondansetron reduces postoperative nausea associated with laparoscopic gastropexy and castration in dogs.
Study design
Prospective clinical study.
Animals
Twenty client-owned, healthy male dogs.
Methods
Dogs were premedicated with dexmedetomidine (2–5 mcg kg–1) and methadone (0.2–0.5 mg kg–1) intramuscularly. General anesthesia was induced with propofol and maintained with an inhalant anesthetic agent. Dogs were randomized into group S (saline 0.1 mL kg–1, intravenously) or group O (ondansetron 0.2 mg kg–1, intravenously). Plasma and serum were collected before premedication and 3 hours postextubation to measure arginine vasopressin (AVP) and cortisol concentrations. Nausea scoring occurred before and 10 minutes after premedication, immediately after extubation, and at 1, 2 and 3 hours postextubation. Data were analyzed by mixed and split-plot anova with Bonferroni adjustment for the number of group comparisons. Significance was set at p < 0.05.
Results
Nausea scores increased over time at 1 (p = 0.01) and 2 (p < 0.001) hours postextubation in both groups compared with before premedication. Median nausea score (0–100 mm) for groups S and O before premedication were 2.5 and 0.5 mm, respectively. At 1 and 2 hours postextubation, group S scored 7.5 and 4.0 mm and group O scored 6.0 and 5.0 mm, respectively. No significant differences in nausea scores within or between groups were observed before premedication and 3 hours postextubation. Cortisol concentrations increased significantly 3 hours postextubation in both groups (p < 0.001) compared with before premedication, with no differences between groups. AVP concentrations showed no significant differences within or between groups.
Conclusions and clinical relevance
Preoperative intravenous administration of ondansetron (0.2 mg kg–1) did not impact postoperative nausea after laparoscopic gastropexy and castration. Investigation of higher doses of ondansetron on the incidence of postoperative nausea and vomiting in dogs after surgery is warranted.
期刊介绍:
Veterinary Anaesthesia and Analgesia is the official journal of the Association of Veterinary Anaesthetists, the American College of Veterinary Anesthesia and Analgesia and the European College of Veterinary Anaesthesia and Analgesia. Its purpose is the publication of original, peer reviewed articles covering all branches of anaesthesia and the relief of pain in animals. Articles concerned with the following subjects related to anaesthesia and analgesia are also welcome:
the basic sciences;
pathophysiology of disease as it relates to anaesthetic management
equipment
intensive care
chemical restraint of animals including laboratory animals, wildlife and exotic animals
welfare issues associated with pain and distress
education in veterinary anaesthesia and analgesia.
Review articles, special articles, and historical notes will also be published, along with editorials, case reports in the form of letters to the editor, and book reviews. There is also an active correspondence section.