生殖器慢性移植物抗宿主病:需要训练有素的妇科医生才能满足的需求。

IF 2.9 4区 医学 Q1 OBSTETRICS & GYNECOLOGY
Climacteric Pub Date : 2024-06-01 Epub Date: 2024-02-28 DOI:10.1080/13697137.2024.2314521
M Á Martínez-Maestre, C Castelo-Branco, A M Calderón, I Espigado, J A Pérez-Simón, C González-Cejudo
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引用次数: 0

摘要

目的:绝经和慢性移植物抗宿主疾病(cGvHD)是异基因造血干细胞移植(alloHSCT)后发病的主要原因。生殖器是移植物抗宿主疾病的靶器官之一,会导致性功能障碍和局部症状,从而影响女性的生活质量。本研究旨在描述生殖器 cGvHD 的发病率和临床特征:方法:我们进行了一项回顾性横断面观察研究,其中包括 85 名接受异体器官移植的女性。所有女性均由经过培训的妇科医生进行诊断和指导。健康相关生活质量通过塞万提斯短式量表进行评估,性功能通过女性性功能指数进行评估:结果:研究中的 17 名女性(20%)被诊断出患有生殖器疱疹。主要主诉为外阴阴道干燥(42.2%)和性生活障碍(29.4%),最常见的体征是出现红斑/红斑(52.9%)。从移植到确诊生殖器 cGvHD 的中位时间为:轻度患者 17 个月,中度患者 25 个月,重度患者 42 个月。生殖器受累cGvHD患者的死亡率为29.4%,而未受累者的死亡率为8.8%(P = 0.012):结论:早期妇科评估可识别轻度生殖器 cGvHD 患者,从而更好地进行治疗并改善预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genital chronic graft-versus-host disease: an unmet need that requires trained gynecologists.

Objective: Menopause and chronic graft-versus-host disease (cGvHD) are the leading causes of morbidity after allogeneic hematopoietic stem cell transplantation (alloHSCT). Genitalia are one of the target organs of cGvHD causing sexual dysfunction and local symptoms, which may impair women's quality of life. The aim of this study is to describe the prevalence and clinical characteristics of genital cGvHD.

Methods: A retrospective cross-sectional observational study was performed including 85 women with alloHSCT. All women were diagnosed and counseled by a trained gynecologist. Health-related quality of life was assessed by the Cervantes Short-Form Scale and sexual function was evaluated by the Female Sexual Function Index.

Results: Seventeen women (20%) included in the study were diagnosed with genital cGvHD. The main complaints were vulvovaginal dryness (42.2%) and dyspareunia (29.4%), the presence of erythema/erythematous plaques (52.9%) being the most frequent sign. Median time from transplant to diagnosis of genital cGvHD was 17 months among those with mild involvement, 25 months for moderate and 42 months for severe forms. Mortality was 29.4% in patients who developed cGvHD with genital involvement versus 8.8% among those without (p = 0.012).

Conclusion: Early gynecological evaluation might allow to identify patients with mild forms of genital cGvHD, potentially enabling better management and improved outcomes.

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来源期刊
Climacteric
Climacteric 医学-妇产科学
CiteScore
1.70
自引率
7.10%
发文量
53
审稿时长
1 months
期刊介绍: Climacteric is the official journal of the International Menopause Society (IMS). As an international peer-reviewed journal it publishes original research and reviews of all aspects of aging in women. Climacteric was founded by the IMS in 1998 and today has become a leading journal in the publication of peer-reviewed papers on the menopause, climacteric and mid-life health. Topics covered include endocrine changes, symptoms attributed to the menopause and their treatment, hormone replacement and alternative therapies, lifestyles, and the counselling and education of peri- and postmenopausal women. Climacteric, published bimonthly, also features regular invited reviews, editorials and commentaries on recent developments. The editorial review board of Climacteric includes leading scientific and clinical experts in the field of midlife medicine and research and is headed by its Editor-in-Chief, Professor Rod Baber of Australia. He and his team of Associate Editors act independently to set a clear editorial policy, co-ordinate peer review, and ensure a rapid response to submitted papers.
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