SIRT1 在潜在有毒微量元素(铅、氟、铝和镉)相关神经发育毒性中的作用

IF 3.4 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Biological Trace Element Research Pub Date : 2024-12-01 Epub Date: 2024-02-28 DOI:10.1007/s12011-024-04116-5
Aqsa Fathima, Newly Bagang, Nitesh Kumar, Somasish Ghosh Dastidar, Smita Shenoy
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引用次数: 0

摘要

中枢神经系统的形成是一个精心策划、错综复杂的过程。对这一过程的任何改变都有可能破坏大脑的结构和运作,从而导致神经系统发育不良。当神经毒性物质出现在发育的早期阶段时,它们就会变得异常危险。在产前,未成熟的大脑极其脆弱,因此与职业接触有关的孕妇面临的风险很高。铅、氟、铝和镉都是可能有毒的微量元素,这些微量元素已被确定为导致多种神经和神经退行性疾病的环境因素。SIRT1 是 sirtuin 家族的成员,因其潜在的神经保护特性而备受关注。SIRT1 是一个令人感兴趣的治疗靶点,因为它通过调节多种途径,在增加神经发生和细胞寿命方面发挥了重要功能。它能在神经元发育过程中促进轴突延伸、神经元生长和树突分支。此外,它还有助于神经发生、突触可塑性、记忆发展和神经保护。本综述总结了 SIRT1 信号通路在潜在有毒微量元素诱导的神经发育毒性中可能发挥的作用,并重点介绍了线粒体生物生成、CREB/BDNF 和 PGC-1α/NRF1/TFAM 等分子通路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of SIRT1 in Potentially Toxic Trace Elements (Lead, Fluoride, Aluminum and Cadmium) Associated Neurodevelopmental Toxicity.

The formation of the central nervous system is a meticulously planned and intricate process. Any modification to this process has the potential to disrupt the structure and operation of the brain, which could result in deficiencies in neurological growth. When neurotoxic substances are present during the early stages of development, they can be exceptionally dangerous. Prenatally, the immature brain is extremely vulnerable and is therefore at high risk in pregnant women associated with occupational exposures. Lead, fluoride, aluminum, and cadmium are examples of possibly toxic trace elements that have been identified as an environmental concern in the aetiology of a number of neurological and neurodegenerative illnesses. SIRT1, a member of the sirtuin family has received most attention for its potential neuroprotective properties. SIRT1 is an intriguing therapeutic target since it demonstrates important functions to increase neurogenesis and cellular lifespan by modulating multiple pathways. It promotes axonal extension, neurite growth, and dendritic branching during the development of neurons. Additionally, it contributes to neurogenesis, synaptic plasticity, memory development, and neuroprotection. This review summarizes the possible role of SIRT1 signalling pathway in potentially toxic trace elements -induced neurodevelopmental toxicity, highlighting some molecular pathways such as mitochondrial biogenesis, CREB/BDNF and PGC-1α/NRF1/TFAM.

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来源期刊
Biological Trace Element Research
Biological Trace Element Research 生物-内分泌学与代谢
CiteScore
8.70
自引率
10.30%
发文量
459
审稿时长
2 months
期刊介绍: Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.
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