白细胞介素：在急性胰腺炎中的病理生理作用。

IF 3 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Archives of Medical Science Pub Date : 2024-01-31 eCollection Date: 2024-01-01 DOI:10.5114/aoms/178183

Saira Rafaqat, Dimitrios Patoulias, Amir Hossein Behnoush, Saima Sharif, Aleksandra Klisic

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引用次数: 0

摘要

急性胰腺炎（AP）是一种常见的炎症状态，其临床过程可导致严重的局部和胰腺外器官功能障碍和衰竭。白细胞介素（ILs）是一种具有生物活性的糖蛋白，主要由巨噬细胞和淋巴细胞产生。根据文献记载，白细胞介素有很多种。但本文仅总结了 ILs 在 AP 中的作用，如 IL-1、IL-2、IL-3、IL-4、IL-5、IL-6、IL-7、IL-8、IL-9、IL-10、IL-11、IL-12、IL-13、IL-14、IL-15、IL-16、IL-17、IL-18、IL-19 和 IL-20。目前正在研究如何调节 IL 的活性，以减少炎症并改善患者的预后。针对特定 IL 的药物可能会被开发出来，以减轻 AP 的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Interleukins: pathophysiological role in acute pancreatitis.

Acute pancreatitis (AP) is a common inflammatory state characterized by a clinical course that can lead to serious local and extrapancreatic organ malfunction and failure. Interleukins (ILs) are biologically active glycoproteins primarily produced by macrophages and lymphocytes. According to the literature, there are many ILs. However, this article represents a summary of the role of ILs in AP, such as IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-14, IL-15, IL-16, IL-17, IL-18, IL-19, and IL-20. The ways to modulate IL activity to reduce inflammation and improve outcomes in individuals with this condition are under investigation. Drugs that target specific ILs might be developed to mitigate the effects of AP.

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来源期刊

Archives of Medical Science 医学-医学：内科

CiteScore

4.90

自引率

7.90%

发文量

139

审稿时长

1.7 months

期刊介绍： Archives of Medical Science (AMS) publishes high quality original articles and reviews of recognized scientists that deal with all scientific medicine. AMS opens the possibilities for young, capable scientists. The journal would like to give them a chance to have a publication following matter-of-fact, professional review by outstanding, famous medical scientists. Thanks to that they will have an opportunity to present their study results and/or receive useful advice about the mistakes they have made so far. The second equally important aim is a presentation of review manuscripts of recognized scientists about the educational capacity, in order that young scientists, often at the beginning of their scientific carrier, could constantly deepen their medical knowledge and be up-to-date with current guidelines and trends in world-wide medicine. The fact that our educational articles are written by world-famous scientists determines their innovation and the highest quality.