{"title":"高效氟康唑负载氧化锌-聚乙烯醇纳米复合材料：生物应用的解释性断点","authors":"Abinash Das, Togam Ringu, Sampad Ghosh, Nabakumar Pramanik","doi":"10.1002/vnl.22098","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <p>Nanotechnology, a versatile field, holds promise in diverse applications, such as advanced pharmaceutical techniques and innovative chemical compound fabrication. Recently, the World Health Organization (WHO) has identified sepsis as a global health priority, attributing most sepsis-related deaths to the underlying infection. Sepsis is a complex disease that manifests in various ways, depending on factors, such as pathogen involved, mode of transmission, and the patient's immune competence. This study focuses on synthesizing zinc oxide (ZnO) through an in-situ precipitation method and employing a solution-based technique to coat the inorganic ZnO nanomaterial with the antimicrobial drug fluconazole (FLZ), resulting in a FLZ-ZnO composite. Further enhancement is achieved by modifying the composite with poly(vinyl alcohol) (PVA) to improve mechanical strength, physicochemical characteristics, and the interfacial network between ZnO and FLZ. Characterization through X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), particle size distribution (PSD), and thermo gravimetric analysis (TGA) confirms the synthesized compounds are stoichiometric in nature. The FLZ-ZnO-PVA nanocomposite demonstrates significant antifungal activity against <i>C. albicans</i> and <i>A. niger</i>, as well as enhanced antibacterial activity against <i>E. coli</i> and <i>S. aureus</i> evaluated through well diffusion technique. In vitro cellular compatibility assessment using the MTT assay with NIH-3T3 cells reveals exceptional viability (above 75%) and negligible cytotoxicity at a concentration of 1.56 μg/mL, indicating high biosafety. The FLZ-ZnO-PVA nanocomposite exhibits outstanding biological performance, making it a promising candidate for clinical applications in preventing sepsis and prospective infections.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Developments and preparation of FLZ-ZnO-PVA nanocomposite.</li>\n \n <li>FLZ-ZnO-PVA nanocomposite shows optimum antimicrobial activity.</li>\n \n <li>FLZ-ZnO-PVA shows cytotoxicity against the mouse embryonic fibroblast cell line.</li>\n \n <li>FLZ-ZnO-PVA could be used as a suitable material for treatment of sepsis.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":17662,"journal":{"name":"Journal of Vinyl & Additive Technology","volume":"30 4","pages":"969-982"},"PeriodicalIF":3.8000,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"High efficacy fluconazole loaded ZnO-poly (vinyl alcohol) nanocomposite: Interpretive breakpoints for biological applications\",\"authors\":\"Abinash Das, Togam Ringu, Sampad Ghosh, Nabakumar Pramanik\",\"doi\":\"10.1002/vnl.22098\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <p>Nanotechnology, a versatile field, holds promise in diverse applications, such as advanced pharmaceutical techniques and innovative chemical compound fabrication. Recently, the World Health Organization (WHO) has identified sepsis as a global health priority, attributing most sepsis-related deaths to the underlying infection. Sepsis is a complex disease that manifests in various ways, depending on factors, such as pathogen involved, mode of transmission, and the patient's immune competence. This study focuses on synthesizing zinc oxide (ZnO) through an in-situ precipitation method and employing a solution-based technique to coat the inorganic ZnO nanomaterial with the antimicrobial drug fluconazole (FLZ), resulting in a FLZ-ZnO composite. Further enhancement is achieved by modifying the composite with poly(vinyl alcohol) (PVA) to improve mechanical strength, physicochemical characteristics, and the interfacial network between ZnO and FLZ. Characterization through X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), particle size distribution (PSD), and thermo gravimetric analysis (TGA) confirms the synthesized compounds are stoichiometric in nature. The FLZ-ZnO-PVA nanocomposite demonstrates significant antifungal activity against <i>C. albicans</i> and <i>A. niger</i>, as well as enhanced antibacterial activity against <i>E. coli</i> and <i>S. aureus</i> evaluated through well diffusion technique. In vitro cellular compatibility assessment using the MTT assay with NIH-3T3 cells reveals exceptional viability (above 75%) and negligible cytotoxicity at a concentration of 1.56 μg/mL, indicating high biosafety. The FLZ-ZnO-PVA nanocomposite exhibits outstanding biological performance, making it a promising candidate for clinical applications in preventing sepsis and prospective infections.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Highlights</h3>\\n \\n <div>\\n <ul>\\n \\n <li>Developments and preparation of FLZ-ZnO-PVA nanocomposite.</li>\\n \\n <li>FLZ-ZnO-PVA nanocomposite shows optimum antimicrobial activity.</li>\\n \\n <li>FLZ-ZnO-PVA shows cytotoxicity against the mouse embryonic fibroblast cell line.</li>\\n \\n <li>FLZ-ZnO-PVA could be used as a suitable material for treatment of sepsis.</li>\\n </ul>\\n </div>\\n </section>\\n </div>\",\"PeriodicalId\":17662,\"journal\":{\"name\":\"Journal of Vinyl & Additive Technology\",\"volume\":\"30 4\",\"pages\":\"969-982\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2024-02-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Vinyl & Additive Technology\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/vnl.22098\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Vinyl & Additive Technology","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/vnl.22098","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
High efficacy fluconazole loaded ZnO-poly (vinyl alcohol) nanocomposite: Interpretive breakpoints for biological applications
Nanotechnology, a versatile field, holds promise in diverse applications, such as advanced pharmaceutical techniques and innovative chemical compound fabrication. Recently, the World Health Organization (WHO) has identified sepsis as a global health priority, attributing most sepsis-related deaths to the underlying infection. Sepsis is a complex disease that manifests in various ways, depending on factors, such as pathogen involved, mode of transmission, and the patient's immune competence. This study focuses on synthesizing zinc oxide (ZnO) through an in-situ precipitation method and employing a solution-based technique to coat the inorganic ZnO nanomaterial with the antimicrobial drug fluconazole (FLZ), resulting in a FLZ-ZnO composite. Further enhancement is achieved by modifying the composite with poly(vinyl alcohol) (PVA) to improve mechanical strength, physicochemical characteristics, and the interfacial network between ZnO and FLZ. Characterization through X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), particle size distribution (PSD), and thermo gravimetric analysis (TGA) confirms the synthesized compounds are stoichiometric in nature. The FLZ-ZnO-PVA nanocomposite demonstrates significant antifungal activity against C. albicans and A. niger, as well as enhanced antibacterial activity against E. coli and S. aureus evaluated through well diffusion technique. In vitro cellular compatibility assessment using the MTT assay with NIH-3T3 cells reveals exceptional viability (above 75%) and negligible cytotoxicity at a concentration of 1.56 μg/mL, indicating high biosafety. The FLZ-ZnO-PVA nanocomposite exhibits outstanding biological performance, making it a promising candidate for clinical applications in preventing sepsis and prospective infections.
Highlights
Developments and preparation of FLZ-ZnO-PVA nanocomposite.
期刊介绍：
Journal of Vinyl and Additive Technology is a peer-reviewed technical publication for new work in the fields of polymer modifiers and additives, vinyl polymers and selected review papers. Over half of all papers in JVAT are based on technology of additives and modifiers for all classes of polymers: thermoset polymers and both condensation and addition thermoplastics. Papers on vinyl technology include PVC additives.
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