胰腺癌声动力治疗策略的最新进展。

Peng Cheng, Shuai Ming, Wei Cao, Jixiao Wu, Qiwei Tian, Jing Zhu, Wei Wei
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引用次数: 0

摘要

胰腺癌是一种常见的消化系统恶性肿瘤,5 年生存率仅为 10%左右。尽管与传统手术、放疗和化疗相比,包括光热疗法和光动力疗法在内的多种微创替代疗法已显示出疗效。然而,这些替代疗法的应用受到其穿透深度的限制,使其难以治疗位于组织深部的胰腺癌。声动力疗法(SDT)是一种很有前景的微创治疗方法,对胰腺癌等深部肿瘤特别有效。然而,胰腺癌的独特特征,包括周围基质致密、高还原性和缺氧的肿瘤微环境,阻碍了 SDT 的有效应用。因此,为了引导 SDT 在胰腺癌治疗中的发展,本综述探讨了这些挑战,研究了目前有效增强 SDT 治疗胰腺癌的策略,并研究了未来提高临床适用性的潜在进展。本文归类于治疗方法与药物发现 > 用于肿瘤疾病的纳米药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Recent advances in sonodynamic therapy strategies for pancreatic cancer.

Recent advances in sonodynamic therapy strategies for pancreatic cancer.

Pancreatic cancer, a prevalent malignancy of the digestive system, has a poor 5-year survival rate of around 10%. Although numerous minimally invasive alternative treatments, including photothermal therapy and photodynamic therapy, have shown effectiveness compared with traditional surgical procedures, radiotherapy, and chemotherapy. However, the application of these alternative treatments is constrained by their depth of penetration, making it challenging to treat pancreatic cancer situated deep within the tissue. Sonodynamic therapy (SDT) has emerged as a promising minimally invasive therapy method that is particularly potent against deep-seated tumors such as pancreatic cancer. However, the unique characteristics of pancreatic cancer, including a dense surrounding matrix, high reductivity, and a hypoxic tumor microenvironment, impede the efficient application of SDT. Thus, to guide the evolution of SDT for pancreatic cancer therapy, this review addresses these challenges, examines current strategies for effective SDT enhancement for pancreatic cancer, and investigates potential future advances to boost clinical applicability. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.

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