Solanum aculeastrum 果实中的细胞毒性成分。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-05-19 DOI:10.1080/14786419.2024.2320738

Nadine-Phalone Tinguep Tchapnda , Ruth Bibiane Njinkou Njambouo , Marguerite Hortence Tchuendem Kenmogne , Pascal Djimeli Douanla , Yoshihito Shiono , Turibio Kuiate Tabopda

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引用次数: 0

摘要

从茄科植物 Solanum aculeastrum 果实的 MeOH/Water (80/20) 提取物中分离出了一种新的三萜类化合物 aculeastrumone A (1)、一种新的三萜类皂甙 aculeastrumoside A (2)，以及 11 种已知化合物 (3-13)。通过详细的一维和二维核磁共振光谱研究以及质谱分析，确定了这些化合物的结构。分离出的化合物针对三种人类癌细胞（MCF-7（乳腺癌）、NCI-H460（肺癌）和 Hela（宫颈癌））和正常人成纤维细胞（BJ）进行了评估。其中，皂苷 2-5、7-8 和 Carpesterol 10 对三种癌细胞株具有显著的细胞毒性活性，IC50 ≤ 10 µM。

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Cytotoxic constituents from the fruit of Solanum aculeastrum

A new triterpene, aculeastrumone A (1), a new triterpene saponin aculeastrumoside A (2), and eleven known compounds (3–13) were isolated from MeOH/Water (80/20) extract of the fruits of Solanum aculeastrum (Solanaceae). Their structures were established by detailed 1D and 2D NMR spectroscopic studies and mass spectrometry. The isolated compounds were evaluated against three human cancer cells ((MCF-7 (breast cancer), NCI-H460 (lung cancer), and Hela (cervical cancer)) and normal human fibroblast (BJ) cell lines. Among them, saponins 2–5, 7–8, and Carpesterol 10 possess significant cytotoxic activity with IC₅₀ ≤ 10 µM against the three cancer cell lines.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.