将三种可食用植物提取物封装成明胶纳米颗粒，作为潜在的纳米保健药剂防治 2 型糖尿病。

IF 3 4区医学 Q2 CHEMISTRY, APPLIED

Journal of microencapsulation Pub Date : 2024-03-01 Epub Date: 2024-02-27 DOI:10.1080/02652048.2024.2313230

Akurange Sujeevi Dammadinna Wickramasinghe, Anoja Priyadarshani Attanayake, Pabasara Kalansuriya

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引用次数: 0

摘要

目的：优化封装植物提取物的明胶纳米颗粒（GNPs）并确定其特性，评估其降糖潜力：方法：采用脱溶法和吸附法制备包裹植物提取物的 GNPs。GNPs 的表征包括负载效率、负载能力、粒度、ZETA 电位、扫描电镜和傅立叶变换红外光谱。利用高脂饮食喂养的链脲佐菌素诱导的 Wistar 大鼠口服葡萄糖耐量试验测定了 GNPs 的降糖活性：结果：优化 GNPs 的负载效率和容量、颗粒平均直径和 zeta 电位分别为 72.45 ± 13.03% w/w、53.05 ± 26.16% w/w、517 ± 48 nm 和 (-)23.43 ± 9.96 mV。封装了 C. grandis、S. auriculata 水提取物和 M. koenigii 70% v/v 乙醇提取物的 GNPs 的降糖活性分别为 17.62%、11.96% 和 13.73%（p 结论）：封装了植物提取物的 GNPs 具有开发成糖尿病纳米保健品的巨大潜力。

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Gelatine nanoparticles encapsulating three edible plant extracts as potential nanonutraceutical agents against type 2 diabetes mellitus.

Aim: To optimise, and characterise gelatine nanoparticles (GNPs) encapsulating plant extracts and evaluate the glucose-lowering potential.

Methods: GNPs encapsulating plant extracts were prepared by desolvation method followed by adsorption. The GNPs were characterised by loading efficiency, loading capacity, particle size, zeta potential, SEM and FTIR. The glucose-lowering activity of GNPs was determined using oral glucose tolerance test in high-fat diet fed streptozotocin-induced Wistar rats.

Results: Loading efficiency and capacity, particle mean diameter, and zeta potential of optimised GNPs 72.45 ± 13.03% w/w, 53.05 ± 26.16% w/w, 517 ± 48 nm and (-)23.43 ± 9.96 mV respectively. GNPs encapsulating aqueous extracts of C. grandis, S. auriculata, and ethanol 70% v/v extracts of M. koenigii showed glucose-lowering activity by 17.62%, 11.96% and 13.73% (p < 0.05) compared to the non-encapsulated extracts. FTIR analysis confirmed the encapsulation of phytoconstituents into GNPs. SEM imaging showed spherical GNPs (174 ± 46 nm).

Conclusion: GNPs encapsulating plant extracts show promising potential to be developed as nanonutraceuticals against diabetes.

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来源期刊

Journal of microencapsulation 工程技术-工程：化工

CiteScore

6.30

自引率

2.60%

发文量

审稿时长

3 months

期刊介绍： The Journal of Microencapsulation is a well-established, peer-reviewed journal dedicated to the publication of original research findings related to the preparation, properties and uses of individually encapsulated novel small particles, as well as significant improvements to tried-and-tested techniques relevant to micro and nano particles and their use in a wide variety of industrial, engineering, pharmaceutical, biotechnology and research applications. Its scope extends beyond conventional microcapsules to all other small particulate systems such as self assembling structures that involve preparative manipulation. The journal covers: Chemistry of encapsulation materials Physics of release through the capsule wall and/or desorption from carrier Techniques of preparation, content and storage Many uses to which microcapsules are put.