阿片受体μ1和儿茶酚-O-甲基转移酶的功能多态性对疼痛神经处理的影响

IF 5 3区医学 Q1 CLINICAL NEUROLOGY

Psychiatry and Clinical Neurosciences Pub Date : 2024-02-25 DOI:10.1111/pcn.13648

Yongjeon Cheong, Seonkyoung Lee, Hidehiko Okazawa, Hirotaka Kosaka, Minyoung Jung

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引用次数: 0

摘要

疼痛是由大脑活动重建的，其主观性来自多种因素的相互作用。本研究旨在了解遗传因素对疼痛神经处理的贡献。我们以阿片受体μ1（OPRM1）A118G（rs1799971）和儿茶酚-O-甲基转移酶（COMT）val158met（rs4680）的单核苷酸多态性（SNP）为重点，研究了这两个疼痛基因如何影响疼痛的处理。

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Effects of functional polymorphisms of opioid receptor mu 1 and catechol-O-methyltransferase on the neural processing of pain

Pain is reconstructed by brain activities and its subjectivity comes from an interplay of multiple factors. The current study aims to understand the contribution of genetic factors to the neural processing of pain. Focusing on the single-nucleotide polymorphism (SNP) of opioid receptor mu 1 (OPRM1) A¹¹⁸G (rs1799971) and catechol-O-methyltransferase (COMT) val¹⁵⁸met (rs4680), we investigated how the two pain genes affect pain processing.

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来源期刊

Psychiatry and Clinical Neurosciences 医学-精神病学

CiteScore

7.40

自引率

4.20%

发文量

181

审稿时长

6-12 weeks

期刊介绍： PCN (Psychiatry and Clinical Neurosciences) Publication Frequency: Published 12 online issues a year by JSPN Content Categories: Review Articles Regular Articles Letters to the Editor Peer Review Process: All manuscripts undergo peer review by anonymous reviewers, an Editorial Board Member, and the Editor Publication Criteria: Manuscripts are accepted based on quality, originality, and significance to the readership Authors must confirm that the manuscript has not been published or submitted elsewhere and has been approved by each author