{"title":"纳米给药系统中的快速成型技术","authors":"Md. Habibur Rahman , Nilufar Yasmin Liza , Khan Rajib Hossain , Dipika Ramdas Kalambhe , Md. Abu Shyeed , Dilwar Hossain Noor","doi":"10.1016/j.pscia.2024.100036","DOIUrl":null,"url":null,"abstract":"<div><p>The adoption of innovative mixing and fabrication technologies in the pharmaceutical industry has inspired research on nano-drugs and expanded the scope of study in the field. Researchers' interest in the recently discovered drug delivery nanoparticles has increased significantly. This interest is especially seen in the specific preparation of nanoparticles as drug carriers through the use of three-dimensional (3D) printing, a modern additive manufacturing (AM) technology. The benefits of 3D printing, especially at the nanoscale, make it an innovative technology that could revolutionize the pharmaceutical and regenerative medicine industries. The laborious creation of intricate structures made possible by nanoscale 3D printing brings up the possibility of developing nanomedicine and producing functioning tissues and organs. The uses of AM in nano drug delivery systems (NDDS) are highlighted in this study, with a focus on how it can improve drug release kinetics, enhance therapeutic efficacy, and minimize side effects. A new era of personalized medicine has begun with the development of patient-specific formulations made possible by the customization capabilities of 3D printing. This review discusses the various uses of AM in NDDS while addressing issues including scalability, biocompatibility, and regulatory concerns. This review highlights the developing integration between AM and nanotechnology in medicine delivery and discusses ongoing research activities and possible solutions. As this innovative technology develops further, it has the potential to completely change the pharmaceutical development field by providing fresh approaches to the complex problems of contemporary healthcare and advancing the ideas behind drug delivery.</p></div>","PeriodicalId":101012,"journal":{"name":"Pharmaceutical Science Advances","volume":"2 ","pages":"Article 100036"},"PeriodicalIF":0.0000,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773216924000023/pdfft?md5=cf73c01823eaed30da7a3590cf259c58&pid=1-s2.0-S2773216924000023-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Additive manufacturing in nano drug delivery systems\",\"authors\":\"Md. Habibur Rahman , Nilufar Yasmin Liza , Khan Rajib Hossain , Dipika Ramdas Kalambhe , Md. 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The uses of AM in nano drug delivery systems (NDDS) are highlighted in this study, with a focus on how it can improve drug release kinetics, enhance therapeutic efficacy, and minimize side effects. A new era of personalized medicine has begun with the development of patient-specific formulations made possible by the customization capabilities of 3D printing. This review discusses the various uses of AM in NDDS while addressing issues including scalability, biocompatibility, and regulatory concerns. This review highlights the developing integration between AM and nanotechnology in medicine delivery and discusses ongoing research activities and possible solutions. 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引用次数: 0
摘要
制药业采用创新的混合和制造技术,激发了纳米药物的研究,扩大了该领域的研究范围。研究人员对最近发现的给药纳米粒子的兴趣大大增加。这种兴趣尤其体现在通过使用三维(3D)打印(一种现代增材制造(AM)技术)制备纳米颗粒作为药物载体。三维打印的优势,尤其是在纳米尺度上的优势,使其成为一项可以彻底改变制药和再生医学行业的创新技术。通过纳米级三维打印技术,可以费力地制造出复杂的结构,这为开发纳米药物和制造功能性组织和器官提供了可能。本研究强调了 AM 在纳米给药系统(NDDS)中的应用,重点是 AM 如何改善药物释放动力学、提高疗效和减少副作用。随着三维打印的定制能力使患者特异配方的开发成为可能,个性化医疗的新时代已经来临。本综述讨论了 AM 在 NDDS 中的各种用途,同时探讨了包括可扩展性、生物相容性和监管问题在内的各种问题。本综述强调了 AM 与纳米技术在给药方面的融合发展,并讨论了正在进行的研究活动和可能的解决方案。随着这项创新技术的进一步发展,它有可能彻底改变制药开发领域,为解决当代医疗保健的复杂问题提供新的方法,并推进药物输送背后的理念。
Additive manufacturing in nano drug delivery systems
The adoption of innovative mixing and fabrication technologies in the pharmaceutical industry has inspired research on nano-drugs and expanded the scope of study in the field. Researchers' interest in the recently discovered drug delivery nanoparticles has increased significantly. This interest is especially seen in the specific preparation of nanoparticles as drug carriers through the use of three-dimensional (3D) printing, a modern additive manufacturing (AM) technology. The benefits of 3D printing, especially at the nanoscale, make it an innovative technology that could revolutionize the pharmaceutical and regenerative medicine industries. The laborious creation of intricate structures made possible by nanoscale 3D printing brings up the possibility of developing nanomedicine and producing functioning tissues and organs. The uses of AM in nano drug delivery systems (NDDS) are highlighted in this study, with a focus on how it can improve drug release kinetics, enhance therapeutic efficacy, and minimize side effects. A new era of personalized medicine has begun with the development of patient-specific formulations made possible by the customization capabilities of 3D printing. This review discusses the various uses of AM in NDDS while addressing issues including scalability, biocompatibility, and regulatory concerns. This review highlights the developing integration between AM and nanotechnology in medicine delivery and discusses ongoing research activities and possible solutions. As this innovative technology develops further, it has the potential to completely change the pharmaceutical development field by providing fresh approaches to the complex problems of contemporary healthcare and advancing the ideas behind drug delivery.