G. Lombardi, Valentina Berti, Andrea Ginestroni, B. Nacmias, S. Sorbi
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引用次数: 0
摘要
淀粉样蛋白-β沉积是脑淀粉样血管病变和阿尔茨海默病痴呆症的病理特征,这两种疾病都会出现认知能力下降和淀粉样蛋白-PET扫描阳性的临床症状。报告中的一个病例涉及一名 82 岁的意大利女性,她最初表现为记忆力减退,后来出现短暂的局灶性神经症状,最后出现两次无症状的脑叶内出血。鉴于这些情况,对脑出血前获得的 MRI 和 PET 成像结果进行了重新考虑和讨论,强调了淀粉样蛋白-PET 在支持脑淀粉样血管病的活体诊断方面的实用性。
The Association Between Positive Amyloid-PET and Cognitive Decline Is Not Always Supportive of Alzheimer’s Disease: Suggestions from a Case Report
Amyloid-β deposition is the pathological hallmark of both cerebral amyloid angiopathy and Alzheimer’s disease dementia, clinical conditions that can share cognitive decline and positive Amyloid-PET scan. A case is reported involving an 82-year-old Italian female who presented initially a memory deficit, later transient focal neurologic episodes, and finally two symptomatic lobar intracerebral hemorrhages. In light of these events, MRI and PET imaging findings, acquired before cerebral hemorrhages, are reconsidered and discussed, highlighting the utility of Amyloid-PET in supporting an in vivo diagnosis of cerebral amyloid angiopathy.