妊娠早期胚胎发育停滞的影响因素分析及其预测模型的构建和验证

IF 1.9 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE
Yongjun Ji, Hong Xu, Jianing Wang, Ruiheng Zhao
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引用次数: 0

摘要

背景:胚胎发育停滞的早期症状并不典型。目前还没有可用于预测胚胎发育停滞的模型工具:探讨孕早期胚胎发育停滞的影响因素,建立风险预测模型:回顾性选取2019年5月至2023年3月苏州大学附属第九医院妇产科277例首次超声检查疑似胚胎发育停滞的患者作为研究对象。根据第二次超声检查(1-2 周后复查)诊断胚胎是否发育停止,将其分为停育组和非停育组。收集两组数据进行分析,筛选出孕早期胚胎发育停滞的影响因素。分别构建逻辑回归模型和随机森林模型。评估两种统计模型的预测性能:在 277 例胚胎发育停滞疑似病例中,88 例最终得到确诊。年龄较大(OR:2.259,P = .017)、超声血流阻力指数(RI)较高(OR:1.728,P = .038)、超声孕囊直径/胚胎头臀长比值(MSD/CRL)较高(OR:1.919,P = .007)、较低的孕酮(OR:0.562,P = .011)和较低的妊娠相关蛋白 A(PAPP-A)(OR:0.495,P = .023)。血管内皮生长因子(VEGF)的低表达(OR:0.618,P = .005)是孕早期胚胎发育停滞的影响因素。根据上述指标建立预测模型,通过测试发现,随机森林模型在预测胚胎发育停滞风险方面优于逻辑回归模型:基于年龄、超声RI、孕酮、PAPP-A、超声MSD/CRL比值和VEGF指数的随机森林模型可帮助临床医生识别胚胎发育停滞的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysis of Influencing Factors of Embryo Development Arrest During Early Pregnancy and Construction and Validation of its Prediction Model.

Context: The early symptoms of embryo development arrest are not typical. There is currently no model tool available to predict embryo development arrest.

Objective: To explore the influencing factors of embryo development arrest in early pregnancy and build a risk prediction model.

Methods: From May 2019 to March 2023, 277 patients suspected of embryonic development arrest during the first ultrasound examination in the Department of Obstetrics and Gynecology of the Ninth Affiliated Hospital of Soochow University were retrospectively selected as the study subjects. They were divided into diapause group and non-diapause group according to the second ultrasound (review after 1-2 weeks) to diagnose whether embryo development arrest. Collect two sets of data for analysis, Screen out the influencing factors of early pregnancy embryo development arrest. The logistic regression model and random forest model were constructed respectively. Evaluate the predictive performance of two statistical models.

Results: Out of 277 suspected cases of embryonic developmental arrest, 88 were ultimately confirmed. Older age (OR: 2.259, P = .017), higher ultrasonic blood flow resistance index (RI) (OR: 1.728, P = .038), higher ultrasonic gestational sac diameter/embryo head hip length ratio (MSD/CRL) (OR:1.919, P = .007), lower progesterone (OR: 0.562, P = .011), and lower pregnancy-associated protein A (PAPP-A) (OR: 0.495, P = .023). The low expression of vascular endothelial growth factor (VEGF) (OR: 0.618, P = .005) was the influencing factor of embryo development arrest in early pregnancy. Building a prediction model based on the above indicators, it was found through testing that the random forest model is superior to the logistic regression model in predicting the risk of embryo development arrest.

Conclusion: A random forest model based on age, ultrasound RI, progesterone, PAPP-A, ultrasound MSD/CRL ratio, and VEGF index can help clinicians identify the risk of embryonic developmental arrest.

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来源期刊
Alternative therapies in health and medicine
Alternative therapies in health and medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
0.90
自引率
0.00%
发文量
219
期刊介绍: Launched in 1995, Alternative Therapies in Health and Medicine has a mission to promote the art and science of integrative medicine and a responsibility to improve public health. We strive to maintain the highest standards of ethical medical journalism independent of special interests that is timely, accurate, and a pleasure to read. We publish original, peer-reviewed scientific articles that provide health care providers with continuing education to promote health, prevent illness, and treat disease. Alternative Therapies in Health and Medicine was the first journal in this field to be indexed in the National Library of Medicine. In 2006, 2007, and 2008, ATHM had the highest impact factor ranking of any independently published peer-reviewed CAM journal in the United States—meaning that its research articles were cited more frequently than any other journal’s in the field. Alternative Therapies in Health and Medicine does not endorse any particular system or method but promotes the evaluation and appropriate use of all effective therapeutic approaches. Each issue contains a variety of disciplined inquiry methods, from case reports to original scientific research to systematic reviews. The editors encourage the integration of evidence-based emerging therapies with conventional medical practices by licensed health care providers in a way that promotes a comprehensive approach to health care that is focused on wellness, prevention, and healing. Alternative Therapies in Health and Medicine hopes to inform all licensed health care practitioners about developments in fields other than their own and to foster an ongoing debate about the scientific, clinical, historical, legal, political, and cultural issues that affect all of health care.
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