2014-2016 年同时使用酒精和大麻与大麻相关问题之间的关联:来自华盛顿小组调查的证据。

IF 4.1 Q1 PHARMACOLOGY & PHARMACY
Yachen Zhu, Yu Ye, Thomas K Greenfield, William C Kerr
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引用次数: 0

摘要

背景:目的:研究华盛顿州娱乐性大麻合法化后,同时使用酒精和大麻者与同时使用大麻者在大麻使用问题风险方面有何不同:我们使用泊松分布的广义估计方程分析了同时使用酒精和大麻(SAM)与同时使用大麻相关问题之间的关联。数据是 2014-2016 年华盛顿州 18 岁及以上饮酒者和大麻使用者(n = 257,47% 为女性)的纵向样本。我们对调查权重进行了调整,以考虑不同的选择概率和响应率。主要结果是过去 6 个月的 CUDIT 问题分量表(范围从 0 到 28),即 7 个 CUDIT 问题项目的总分,其中不包括涉及大麻使用频率的 3 个项目。协变量包括大麻使用频率(每天/接近每天使用、经常使用或不经常使用)、大麻日用量、酒精日用量、小组调查周期、医用大麻推荐、驾车到达最近大麻销售点的时间、开始使用大麻的年龄以及其他人口统计学因素:调整协变量后,我们发现与同时使用相比,SAM 与 CUDIT 问题分量表显著正相关(IRR = 1.68,95% CI:1.25-2.27,p 结论:SAM 与 CUDIT 问题分量表显著正相关:本研究强调了除大麻使用频率外,SAM 对预测大麻相关问题的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations between simultaneous use of alcohol and cannabis and cannabis-related problems in 2014-2016: evidence from the Washington panel survey.

Background: To address the research question of how simultaneous users of alcohol and cannabis differ from concurrent users in risk of cannabis use problems after the recreational marijuana legalization in Washington State.

Methods: We used generalized estimating equations with a Poisson distribution to analyze the association between simultaneous use of alcohol and marijuana (SAM) and cannabis-related problems compared to concurrent use. The data is a longitudinal sample of drinkers and cannabis users (n = 257, 47% female) aged 18 years and older from Washington State in 2014-2016. We adjusted for survey weights to account for differential probability of selection and response rates. The primary outcome is the past-six-month CUDIT problem subscale (ranging from 0 to 28), which is the total score for seven CUDIT problem items, after excluding the three items that covered marijuana use frequency. Covariates include marijuana use frequency (daily/near daily use, regular use, or infrequent use), marijuana daily quantity, alcohol daily volume, panel survey cycle, medical marijuana recommendation, driving time to nearest marijuana outlet, age of marijuana use onset, and other demographics.

Results: After adjusting for covariates, we found that compared to concurrent use, SAM was significantly positively associated with CUDIT problem subscale (IRR = 1.68, 95% CI: 1.25-2.27, p < 0.001); daily/near daily use of marijuana was strongly significantly associated with CUDIT problem subscale compared with infrequent use (IRR = 5.1, 2.71-9.57, p < 0.001) or regular use (IRR = 3.05, 1.91-4.85, p < 0.001). Secondary analyses using CUDIT total score as the outcome also showed a significant positive association with SAM compared to concurrent use (IRR = 1.17, 1.02-1.34, p < 0.05).

Conclusions: This study highlighted the importance of SAM, in addition to cannabis use frequency for predicting cannabis-related problems.

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