中性粒细胞/淋巴细胞比率和血小板/淋巴细胞比率对急性脑卒中患者死亡率的预后作用。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-01 DOI:10.1016/j.hipert.2023.10.002

R.F. Cáceda-Samamé , M.R. Vela-Salazar , R. Alejandro-Salinas , A.P. Llamo-Vilcherrez , C.J. Toro-Huamanchumo

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引用次数: 0

摘要

目的评估中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）对秘鲁一家医院收治的急性中风患者死亡率的预后影响：设计：回顾性队列研究：患者：年龄≥18 岁的患者干预措施：无：无。主要利益变量：中性粒细胞与淋巴细胞比率、血小板与淋巴细胞比率和死亡率：结果：共纳入 165 名患者。平均年龄为（66.1±14.2）岁，59.4%为男性。只有 NLR 的性能优于 0.7（AUC：0.75；95%CI：0.65-0.85），调整混杂因素后，NLR 水平升高与死亡风险增加有关（aRR：3.66；95%CI：1.77-8.85）：结论：中性粒细胞与淋巴细胞比值对急性卒中患者的死亡率具有可接受的预后作用。结论：中性粒细胞与淋巴细胞比值对急性卒中患者死亡率的预后表现尚可接受，可考虑使用该比值对患者进行风险分层，并及时考虑替代治疗和管理。

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Prognostic performance of neutrophil/lymphocyte ratio and platelet/lymphocyte ratio for mortality in patients with acute stroke

Objective

To evaluate the prognostic performance of the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) for mortality in patients with acute stroke treated at a Peruvian hospital.

Design

Retrospective cohort study.

Setting

Tertiary care hospital.

Patients

Patients aged ≥18 years with a diagnosis of acute stroke and admitted to the hospital from May 2019 to June 2021.

Interventions

None.

Main variables of interests

Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mortality.

Results

A total of 165 patients were included. The mean age was 66.1 ± 14.2 years, and 59.4% were male. Only NLR had a performance superior to 0.7 (AUC: 0.75; 95%CI: 0.65–0.85), and its elevated levels were associated with an increased risk of mortality (aRR: 3.66; 95%CI: 1.77–8.85) after adjusting for confounders.

Conclusion

The neutrophil-to-lymphocyte ratio has an acceptable prognostic performance for mortality in patients with acute stroke. Its use may be considered to stratify patients’ risk and to consider timely alternative care and management.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.