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引用次数: 0
摘要
熵表示动态系统的不规则性,熵越高表示不规则性越高,过渡状态越多。在人脑中,越来越多的人使用静息状态 fMRI(rs-fMRI)来评估区域脑熵(BEN),而在基于任务的 fMRI 中区域 BEN 的变化却鲜有研究。本研究的目的是利用人类连接组计划(HCP)的大型数据来描述任务引起的区域 BEN 变化。为了控制分块设计的潜在调节作用,仅从任务条件下获取的 fMRI 图像中计算任务-fMRI 的 BEN(任务 BEN),然后与 rs-fMRI 的 BEN(静息 BEN)进行比较。此外,根据任务-FMRI 运行的控制块单独计算 BEN(控制 BEN),并与任务 BEN 进行比较。最后,将控制 BEN 与静息 BEN 进行比较,以检验控制条件下的残余任务效应。与静息状态相比,任务表现一致导致外周皮层区域的 BEN 减少,而感觉运动和感知网络中心部分的 BEN 增加。对照组的 BEN 与静息状态的 BEN 相比,显示出相似的熵变化,这表明任务效应有很大的残余。与对照组 BEN 相比,任务组 BEN 的特点是枕叶、眶额叶和顶叶区域的熵值降低。
Entropy indicates irregularity of a dynamic system, with higher entropy indicating higher irregularity and more transit states. In the human brain, regional brain entropy (BEN) has been increasingly assessed using resting state fMRI (rs-fMRI), while changes of regional BEN during task-based fMRI have been scarcely studied. The purpose of this study is to characterize task-induced regional BEN alterations using the large Human Connectome Project (HCP) data. To control the potential modulation by the block design, BEN of task-fMRI was calculated from the fMRI images acquired during the task conditions only (task BEN) and then compared to BEN of rs-fMRI (resting BEN). Moreover, BEN was separately calculated from the control blocks of the task-fMRI runs (control BEN) and compared to task BEN. Finally, control BEN was compared to resting BEN to test for residual task effects in the control condition. With respect to resting state, task performance unanimously induced BEN reduction in the peripheral cortical area and BEN increase in the centric part of the sensorimotor and perception networks. Control compared to resting BEN showed similar entropy alterations, suggesting large residual task effects. Task compared to control BEN was characterized by reduced entropy in occipital, orbitofrontal, and parietal regions.
期刊介绍:
The Journal of Neuroscience Research (JNR) publishes novel research results that will advance our understanding of the development, function and pathophysiology of the nervous system, using molecular, cellular, systems, and translational approaches. JNR covers both basic research and clinical aspects of neurology, neuropathology, psychiatry or psychology.
The journal focuses on uncovering the intricacies of brain structure and function. Research published in JNR covers all species from invertebrates to humans, and the reports inform the readers about the function and organization of the nervous system, with emphasis on how disease modifies the function and organization.