神经精神疾病中 2 型多巴胺受体的变化:大规模正电子发射计算机队列

IF 3.4 2区 医学 Q2 NEUROIMAGING
Tuulia Malén , Severi Santavirta , Sven De Maeyer , Jouni Tuisku , Valtteri Kaasinen , Tuomas Kankare , Janne Isojärvi , Juha Rinne , Jarmo Hietala , Pirjo Nuutila , Lauri Nummenmaa
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引用次数: 0

摘要

目的多巴胺能功能异常与运动、精神病和情感症状有关,但研究通常将单一患者群体与健康对照组进行比较。方法在此,我们使用[11C]raclopride正电子发射断层扫描(PET)数据研究了纹状体(尾状核、凹凸核和普鲁曼)和丘脑2型多巴胺受体(D2R)可用性的变化,这些数据来自437人的大样本,包括健康对照组、帕金森病(PD)患者、抗精神病药物无效的精神分裂症患者、严重暴力行为患者、病态赌博患者、抑郁症患者和超重患者。我们分析了 D2R 可用性的地区群体差异。结果患有帕金森病的受试者的 D2R 可用性下降最为明显。总体而言,各组的 D2R 可用性显示出较高的区域间相关性,而这种模式在暴力犯罪者中较弱。精神分裂症、病态赌博、抑郁症或超重的受试者在区域受体可用性或区域间相关性方面都没有表现出明显的变化。特定区域的受体可用性与运动症状的关系更为密切,而区域间的耦合则可能在暴力中受到破坏。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Alterations in type 2 dopamine receptors across neuropsychiatric conditions: A large-scale PET cohort

Alterations in type 2 dopamine receptors across neuropsychiatric conditions: A large-scale PET cohort

Purpose

Aberrant dopaminergic function is linked with motor, psychotic, and affective symptoms, but studies have typically compared a single patient group with healthy controls.

Methods

Here, we investigated the variation in striatal (caudate nucleus, nucleus accumbens, and putamen) and thalamic type 2 dopamine receptor (D2R) availability using [11C]raclopride positron emission tomography (PET) data from a large sample of 437 humans including healthy controls, and subjects with Parkinson’s disease (PD), antipsychotic-naïve schizophrenia, severe violent behavior, pathological gambling, depression, and overweight. We analyzed regional group differences in D2R availability. We also analyzed the interregional correlation in D2R availability within each group.

Results

Subjects with PD showed the clearest decline in D2R availability. Overall, the groups showed high interregional correlation in D2R availability, while this pattern was weaker in violent offenders. Subjects with schizophrenia, pathological gambling, depression, or overweight did not show clear changes in either the regional receptor availability or the interregional correlation.

Conclusion

We conclude that the dopaminergic changes in neuropsychiatric conditions might not only affect the overall receptor availability but also how coupled regions are across people. The region-specific receptor availability more profoundly links to the motor symptoms, while the between-region coupling might be disrupted in violence.

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来源期刊
Neuroimage-Clinical
Neuroimage-Clinical NEUROIMAGING-
CiteScore
7.50
自引率
4.80%
发文量
368
审稿时长
52 days
期刊介绍: NeuroImage: Clinical, a journal of diseases, disorders and syndromes involving the Nervous System, provides a vehicle for communicating important advances in the study of abnormal structure-function relationships of the human nervous system based on imaging. The focus of NeuroImage: Clinical is on defining changes to the brain associated with primary neurologic and psychiatric diseases and disorders of the nervous system as well as behavioral syndromes and developmental conditions. The main criterion for judging papers is the extent of scientific advancement in the understanding of the pathophysiologic mechanisms of diseases and disorders, in identification of functional models that link clinical signs and symptoms with brain function and in the creation of image based tools applicable to a broad range of clinical needs including diagnosis, monitoring and tracking of illness, predicting therapeutic response and development of new treatments. Papers dealing with structure and function in animal models will also be considered if they reveal mechanisms that can be readily translated to human conditions.
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