转移性甲状腺髓样癌的 68Ga 前列腺特异性膜抗原摄取量

IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Molecular Imaging and Radionuclide Therapy Pub Date : 2024-02-22 DOI:10.4274/mirt.galenos.2023.47855

Kübra Şahin, Ali Kibar, Cansu Güneren, Muhammet Sait Sağer, Kerim Sönmezoğlu

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引用次数: 0

摘要

本病例是一名 58 岁的晚期甲状腺髓样癌患者，曾接受过不同类型的治疗。随访期间，患者的降钙素原和癌胚抗原水平不断升高。18F-氟脱氧葡萄糖（FDG）和68Ga-DOTATATE正电子发射断层扫描/计算机断层扫描（PET/CT）发现了不同程度摄取的转移性淋巴结、肝脏和骨转移灶。68Ga 前列腺特异性膜抗原（PSMA）正电子发射断层扫描/计算机断层扫描（PET/CT）是为了探索患者是否有机会接受 PSMA 靶向放射性核素治疗，结果发现大多数转移病灶中 PSMA 表达增加，甚至其中一些病灶的 PSMA 摄取量高于 18F-FDG 和 68Ga-DOTATATE。

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⁶⁸Ga Prostate-specific Membrane Antigen Uptake in Metastatic Medullary Thyroid Carcinoma.

We present the case of a 58-year-old man with advanced medullary thyroid carcinoma who had a treatment history with different types of modalities. In the follow-up, the patient had rising calcitonin and CEA levels. Metastatic lymph nodes, liver, and bone metastases with varying degrees of uptake were detected on ¹⁸F-fluorodeoxyglucose (FDG) and ⁶⁸Ga-DOTATATE positron emission tomography/computed tomography (PET/CT). ⁶⁸Ga prostate-specific membrane antigen (PSMA) PET/CT was performed to explore whether the patient might have a chance for PSMA-targeted radionuclide therapy, and increased PSMA expression was noted in most of the metastatic lesions, even some of which have higher PSMA uptake than ¹⁸F-FDG and ⁶⁸Ga-DOTATATE.

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来源期刊

Molecular Imaging and Radionuclide Therapy RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Molecular Imaging and Radionuclide Therapy (Mol Imaging Radionucl Ther, MIRT) is publishes original research articles, invited reviews, editorials, short communications, letters, consensus statements, guidelines and case reports with a literature review on the topic, in the field of molecular imaging, multimodality imaging, nuclear medicine, radionuclide therapy, radiopharmacy, medical physics, dosimetry and radiobiology.