膳食硫胺素摄入量与认知能力健康的中国老年人认知能力下降风险之间的 "J "形关系。

IF 5.3 3区医学 Q1 PSYCHIATRY

General Psychiatry Pub Date : 2024-02-20 eCollection Date: 2024-01-01 DOI:10.1136/gpsych-2023-101311

Chengzhang Liu, Qiguo Meng, Yuanxiu Wei, Xinyue Su, Yuanyuan Zhang, Panpan He, Chun Zhou, Mengyi Liu, Ziliang Ye, Xianhui Qin

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引用次数: 0

摘要

背景：目的：研究认知健康的中国老年人膳食中硫胺素摄入量与认知能力下降之间的关系：研究共纳入了3106名能够完成重复认知功能测试的参与者。膳食营养素摄入量信息通过3天膳食回顾和3天食物称重法收集，以评估食用油和调味品的摄入量。认知能力下降的定义是根据认知状况电话访谈的子集项目得出的总体或综合认知得分的5年下降率：中位随访时间为 5.9 年。膳食中硫胺素的摄入量与5年期总体和综合认知评分的下降率呈 "J "形关系，拐点为0.68毫克/天（95%置信区间（CI）：0.56至0.80），膳食中硫胺素的摄入量为0.60-1.00毫克/天时风险最小。在拐点之前，硫胺素摄入量与认知能力下降无明显关联。超过拐点后，硫胺素摄入量每增加一个单位（毫克/天），5年内的总分就会显著下降4.24（95% CI：2.22至6.27）分，综合得分显著下降0.49（95% CI：0.23至0.76）个标准单位。在高血压、肥胖和不吸烟的人群中，硫胺素摄入量与认知能力下降之间的正相关性更强（均为 p 结论：这项研究显示，在认知能力健康的中国老年人中，膳食硫胺素摄入量与认知能力下降之间呈 "J "形关联，拐点在0.68毫克/天，而膳食硫胺素摄入量在0.60-1.00毫克/天时风险最小。

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J-shaped association between dietary thiamine intake and the risk of cognitive decline in cognitively healthy, older Chinese individuals.

Background: The prospective association of dietary thiamine intake with the risk of cognitive decline among the general older adults remains uncertain.

Aims: To investigate the association between dietary thiamine intake and cognitive decline in cognitively healthy, older Chinese individuals.

Methods: The study included a total of 3106 participants capable of completing repeated cognitive function tests. Dietary nutrient intake information was collected through 3-day dietary recalls and using a 3-day food-weighed method to assess cooking oil and condiment consumption. Cognitive decline was defined as the 5-year decline rate in global or composite cognitive scores based on a subset of items from the Telephone Interview for Cognitive Status-modiﬁed.

Results: The median follow-up duration was 5.9 years. There was a J-shaped relationship between dietary thiamine intake and the 5-year decline rate in global and composite cognitive scores, with an inflection point of 0.68 mg/day (95% confidence interval (CI): 0.56 to 0.80) and a minimal risk at 0.60-1.00 mg/day of dietary thiamine intake. Before the inflection point, thiamine intake was not significantly associated with cognitive decline. Beyond the inflection point, each unit increase in thiamine intake (mg/day) was associated with a significant decrease of 4.24 (95% CI: 2.22 to 6.27) points in the global score and 0.49 (95% CI: 0.23 to 0.76) standard units in the composite score within 5 years. A stronger positive association between thiamine intake and cognitive decline was observed in those with hypertension, obesity and those who were non-smokers (all p<0.05).

Conclusions: This study revealed a J-shaped association between dietary thiamine intake and cognitive decline in cognitively healthy, older Chinese individuals, with an inflection point at 0.68 mg/day and a minimal risk at 0.60-1.00 mg/day of dietary thiamine intake.

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来源期刊

General Psychiatry 医学-精神病学

CiteScore

21.90

自引率

2.50%

发文量

848

期刊介绍： General Psychiatry (GPSYCH), an open-access journal established in 1959, has been a pioneer in disseminating leading psychiatry research. Addressing a global audience of psychiatrists and mental health professionals, the journal covers diverse topics and publishes original research, systematic reviews, meta-analyses, forums on topical issues, case reports, research methods in psychiatry, and a distinctive section on 'Biostatistics in Psychiatry'. The scope includes original articles on basic research, clinical research, community-based studies, and ecological studies, encompassing a broad spectrum of psychiatric interests.