{"title":"住宅暴露于霉菌、潮湿和室内空气污染与呼吸道感染风险：丹麦国家出生队列中 11 和 12 岁儿童的研究。","authors":"Jonathan Groot, Amélie Keller, Torben Sigsgaard, Steffen Loft, Anne-Marie Nybo Andersen","doi":"10.1007/s10654-024-01101-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The burden of respiratory tract infections (RTIs) is high in childhood. Several residential exposures may affect relative rates.</p><p><strong>Objectives: </strong>To determine risk of RTIs in children ages 11 and 12 by residential exposures.</p><p><strong>Methods: </strong>We included children in the Danish National Birth Cohort (DNBC) at ages 11 and 12. We estimated incidence risk ratios (IRR) and 95% confidence intervals (CI) for counts of RTIs within the last year by exposure to mold/dampness, gas stove usage, summer and winter candle-burning, fireplace usage, cats and dogs indoors, and farmhouse living. We also estimated IRR and 95% CI for RTIs for predicted scores of four extracted factors ('owned house', 'mold and dampness', 'candles', and 'density') from exploratory factor analyses (EFA).</p><p><strong>Results: </strong>We included 42 720 children with complete data. Mold/dampness was associated with all RTIs (common cold: IRR<sub>adj</sub> 1.09[1.07, 1.12]; influenza: IRR<sub>adj</sub> 1.10 [1.05, 1.15]; tonsillitis: IRR<sub>adj</sub> 1.19 [1.10, 1.28]; conjunctivitis: IRR<sub>adj</sub> 1.16 [1.02, 1.32]; and doctor-diagnosed pneumonia: IRR<sub>adj</sub> 1.05 [0.90, 1.21]), as was the EFA factor 'mold/dampness' for several outcomes. Gas stove usage was associated with conjunctivitis (IRR<sub>adj</sub> 1.25 [1.05, 1.49]) and with doctor-diagnosed pneumonia (IRR<sub>adj</sub> 1.14 [0.93, 1.39]). Candle-burning during summer, but not winter, was associated with several RTIs, for tonsillitis in a dose-dependent fashion (increasing weekly frequencies vs. none: [IRR<sub>adj</sub> 1.06 [0.98, 1.14], IRR<sub>adj</sub> 1.16 [1.04, 1.30], IRR<sub>adj</sub> 1.23 [1.06, 1.43], IRR<sub>adj</sub> 1.29 [1.00, 1.67], and IRR<sub>adj</sub> 1.41 [1.12, 1.78]).</p><p><strong>Conclusion: </strong>Residential exposures, in particular to mold and dampness and to a lesser degree to indoor combustion sources, are related to the occurrence of RTIs in children.</p>","PeriodicalId":11907,"journal":{"name":"European Journal of Epidemiology","volume":" ","pages":"299-311"},"PeriodicalIF":7.7000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10994992/pdf/","citationCount":"0","resultStr":"{\"title\":\"Residential exposure to mold, dampness, and indoor air pollution and risk of respiratory tract infections: a study among children ages 11 and 12 in the Danish National Birth Cohort.\",\"authors\":\"Jonathan Groot, Amélie Keller, Torben Sigsgaard, Steffen Loft, Anne-Marie Nybo Andersen\",\"doi\":\"10.1007/s10654-024-01101-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The burden of respiratory tract infections (RTIs) is high in childhood. Several residential exposures may affect relative rates.</p><p><strong>Objectives: </strong>To determine risk of RTIs in children ages 11 and 12 by residential exposures.</p><p><strong>Methods: </strong>We included children in the Danish National Birth Cohort (DNBC) at ages 11 and 12. We estimated incidence risk ratios (IRR) and 95% confidence intervals (CI) for counts of RTIs within the last year by exposure to mold/dampness, gas stove usage, summer and winter candle-burning, fireplace usage, cats and dogs indoors, and farmhouse living. We also estimated IRR and 95% CI for RTIs for predicted scores of four extracted factors ('owned house', 'mold and dampness', 'candles', and 'density') from exploratory factor analyses (EFA).</p><p><strong>Results: </strong>We included 42 720 children with complete data. Mold/dampness was associated with all RTIs (common cold: IRR<sub>adj</sub> 1.09[1.07, 1.12]; influenza: IRR<sub>adj</sub> 1.10 [1.05, 1.15]; tonsillitis: IRR<sub>adj</sub> 1.19 [1.10, 1.28]; conjunctivitis: IRR<sub>adj</sub> 1.16 [1.02, 1.32]; and doctor-diagnosed pneumonia: IRR<sub>adj</sub> 1.05 [0.90, 1.21]), as was the EFA factor 'mold/dampness' for several outcomes. Gas stove usage was associated with conjunctivitis (IRR<sub>adj</sub> 1.25 [1.05, 1.49]) and with doctor-diagnosed pneumonia (IRR<sub>adj</sub> 1.14 [0.93, 1.39]). Candle-burning during summer, but not winter, was associated with several RTIs, for tonsillitis in a dose-dependent fashion (increasing weekly frequencies vs. none: [IRR<sub>adj</sub> 1.06 [0.98, 1.14], IRR<sub>adj</sub> 1.16 [1.04, 1.30], IRR<sub>adj</sub> 1.23 [1.06, 1.43], IRR<sub>adj</sub> 1.29 [1.00, 1.67], and IRR<sub>adj</sub> 1.41 [1.12, 1.78]).</p><p><strong>Conclusion: </strong>Residential exposures, in particular to mold and dampness and to a lesser degree to indoor combustion sources, are related to the occurrence of RTIs in children.</p>\",\"PeriodicalId\":11907,\"journal\":{\"name\":\"European Journal of Epidemiology\",\"volume\":\" \",\"pages\":\"299-311\"},\"PeriodicalIF\":7.7000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10994992/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Epidemiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10654-024-01101-z\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/2/23 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Epidemiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10654-024-01101-z","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/2/23 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Residential exposure to mold, dampness, and indoor air pollution and risk of respiratory tract infections: a study among children ages 11 and 12 in the Danish National Birth Cohort.
Background: The burden of respiratory tract infections (RTIs) is high in childhood. Several residential exposures may affect relative rates.
Objectives: To determine risk of RTIs in children ages 11 and 12 by residential exposures.
Methods: We included children in the Danish National Birth Cohort (DNBC) at ages 11 and 12. We estimated incidence risk ratios (IRR) and 95% confidence intervals (CI) for counts of RTIs within the last year by exposure to mold/dampness, gas stove usage, summer and winter candle-burning, fireplace usage, cats and dogs indoors, and farmhouse living. We also estimated IRR and 95% CI for RTIs for predicted scores of four extracted factors ('owned house', 'mold and dampness', 'candles', and 'density') from exploratory factor analyses (EFA).
Results: We included 42 720 children with complete data. Mold/dampness was associated with all RTIs (common cold: IRRadj 1.09[1.07, 1.12]; influenza: IRRadj 1.10 [1.05, 1.15]; tonsillitis: IRRadj 1.19 [1.10, 1.28]; conjunctivitis: IRRadj 1.16 [1.02, 1.32]; and doctor-diagnosed pneumonia: IRRadj 1.05 [0.90, 1.21]), as was the EFA factor 'mold/dampness' for several outcomes. Gas stove usage was associated with conjunctivitis (IRRadj 1.25 [1.05, 1.49]) and with doctor-diagnosed pneumonia (IRRadj 1.14 [0.93, 1.39]). Candle-burning during summer, but not winter, was associated with several RTIs, for tonsillitis in a dose-dependent fashion (increasing weekly frequencies vs. none: [IRRadj 1.06 [0.98, 1.14], IRRadj 1.16 [1.04, 1.30], IRRadj 1.23 [1.06, 1.43], IRRadj 1.29 [1.00, 1.67], and IRRadj 1.41 [1.12, 1.78]).
Conclusion: Residential exposures, in particular to mold and dampness and to a lesser degree to indoor combustion sources, are related to the occurrence of RTIs in children.
期刊介绍：
The European Journal of Epidemiology, established in 1985, is a peer-reviewed publication that provides a platform for discussions on epidemiology in its broadest sense. It covers various aspects of epidemiologic research and statistical methods. The journal facilitates communication between researchers, educators, and practitioners in epidemiology, including those in clinical and community medicine. Contributions from diverse fields such as public health, preventive medicine, clinical medicine, health economics, and computational biology and data science, in relation to health and disease, are encouraged. While accepting submissions from all over the world, the journal particularly emphasizes European topics relevant to epidemiology. The published articles consist of empirical research findings, developments in methodology, and opinion pieces.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
