单宁酸对镉和镍共同暴露诱导的 BALB/c 小鼠肝-肾毒性的细胞和基因保护潜力

IF 3.4 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Biological Trace Element Research Pub Date : 2024-12-01 Epub Date: 2024-02-23 DOI:10.1007/s12011-024-04117-4
Madhu Sharma, Pooja Devi, Surbhi Kaushal, Aitizaz Ul-Ahsan, Sweety Mehra, Muskan Budhwar, Mani Chopra
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引用次数: 0

摘要

单宁酸(TA)是一种金属螯合多酚,在金属解毒过程中发挥着重要作用,但它在这些重金属共同暴露过程中的调节作用还有待探索。镉(Cd)和镍(Ni)是环境中的无机危险化学品。人类很容易同时接触到镉和镍,但这两种金属的毒理学相互作用还不十分明确。本研究旨在研究 TA 对 BALB/c 小鼠因同时接触镉和镍而引起的肝肾毒性的预防作用。在目前的调查中,金属中毒组的氧化应激增加,表现为脂质过氧化程度升高和内源性抗氧化酶显著降低。在金属处理组中还发现了肝肾血清标志物的改变、DNA 断裂和组织学改变。目前的研究表明,镉的毒性比镍强,当同时暴露于镉和镍时,会出现叠加效应、次叠加效应和有害效应。用 TA 进行预防性治疗可明显恢复脂质过氧化物(LPO)、非酶和酶抗氧化剂的水平。此外,它还恢复了血清生物标志物水平、DNA 损伤和特定组织的组织结构。TA具有金属螯合和抗氧化特性,对镉镍共同暴露引起的肝肾损伤具有细胞和基因保护潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cyto and Genoprotective Potential of Tannic Acid Against Cadmium and Nickel Co-exposure Induced Hepato-Renal Toxicity in BALB/c Mice.

Tannic acid (TA) is a metal chelating polyphenol that plays a crucial role in metal detoxification, but its modulatory role in co-exposure of these heavy metals' exposure needs to be explored. Cadmium (Cd) and nickel (Ni) are inorganic hazardous chemicals in the environment. Humans are prone to be exposed to the co-exposure of Cd and Ni, but the toxicological interactions of these metals are poorly defined. Present study was undertaken to study the preventive role of TA in Cd-Ni co-exposure-evoked hepato-renal toxicity in BALB/c mice. In the current investigation, increased oxidative stress in metal intoxicated groups was confirmed by elevated peroxidation of the lipids and significant lowering of endogenous antioxidant enzymes. Altered hepato-renal serum markers, DNA fragmentation, and histological alterations were also detected in the metal-treated groups. Present study revealed that Cd is a stronger toxicant than Ni and when co-exposure was administered, additive, sub-additive, and detrimental effects were observed. Prophylactic treatment with TA significantly reinstated the levels of lipid peroxidation (LPO), non-enzymatic, and enzymatic antioxidants. Moreover, it also restored the serum biomarker levels, DNA damage, and histoarchitecture of the given tissues. TA due to its metal chelating and anti-oxidative properties exhibited cyto- and genoprotective potential against Cd-Ni co-exposure-induced hepatic and renal injury.

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来源期刊
Biological Trace Element Research
Biological Trace Element Research 生物-内分泌学与代谢
CiteScore
8.70
自引率
10.30%
发文量
459
审稿时长
2 months
期刊介绍: Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.
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