神经性贪食症患者的非典型社会认知处理:对患者思考他人心理状态的 fMRI 研究

IF 2.3 4区 医学 Q2 PSYCHIATRY
Rio Kamashita, Rikukage Setsu, Noriko Numata, Yasuko Koga, Michiko Nakazato, Koji Matsumoto, Hiroki Ando, Yoshitada Masuda, Sertap Maral, Eiji Shimizu, Yoshiyuki Hirano
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引用次数: 0

摘要

进食障碍和饮食失调是严重影响患者生活的严重精神障碍。尤其是神经性厌食症(AN)或神经性贪食症(BN)患者的社会认知能力似乎很差。许多研究表明,神经性厌食症患者社交认知能力差与大脑反应有关。然而,很少有研究探讨社会认知与神经性厌食症之间的关系。因此,我们研究了哪些脑区会影响 BN 患者的社会认知能力。我们使用基于任务的功能性磁共振成像(fMRI)检查了社交认知任务和 "读心测试"(RMET)中的大脑反应。在进行功能磁共振成像时,22 名患有 BN 的女性和 22 名健康女性(HW)参加了 RMET 测试。参与者还完成了进食障碍临床测量爱丁堡暴食调查测试(BITE)和进食障碍检查问卷(EDE-Q)、患者健康问卷(PHQ-9)抑郁测量和广泛性焦虑症(GAD-7)焦虑测量。在 RMET 评分方面,BN 和 HW 女性之间没有发现差异。两组患者的大脑区域都出现了与社会认知相关的激活。在任务过程中,两组之间的 BOLD 信号没有显示出差异(P < 0.05,多重比较的家族误差校正)。然而,BN 的右角回、腹侧间脑、丘脑本部、颞极和颞中回有更强的激活趋势(p < 0.001,多重比较未校正)。此外,HW 的 RMET 分数与两个区域的激活呈正相关:内侧前额叶皮层(mPFC)和前扣带回皮层(ACC);但在患有 BN 的女性中未观察到显著的相关性。虽然内侧前额叶皮层和前扣带回皮层的激活与 HW 的 RMET 分数呈正相关,但在 BN 患者中却未观察到相关性。因此,患有 BN 的女性在思考他人的精神状态时可能会表现出调节性神经处理。为了更好地了解 BN 患者的社会认知能力,我们需要进一步研究 BN 患者的神经加工过程。umin,umin000010220。2013年3月13日注册,https://rctportal.niph.go.jp/s/detail/um?trial_id=UMIN000010220
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Atypical social cognition processing in bulimia nervosa: an fMRI study of patients thinking of others’ mental states
Feeding and eating disorders are severe mental disorders that gravely affect patients’ lives. In particular, patients with anorexia nervosa (AN) or bulimia nervosa (BN) appear to have poor social cognition. Many studies have shown the relationship between poor social cognition and brain responses in AN. However, few studies have examined the relationship between social cognition and BN. Therefore, we examined which brain regions impact the ability for social cognition in patients with BN. We used task-based functional magnetic resonance imaging (fMRI) to examine brain responses during a social cognition task and the Reading Mind in the Eyes Test (RMET). During the fMRI, 22 women with BN and 22 healthy women (HW) took the RMET. Participants also completed the eating disorder clinical measures Bulimic Investigatory Test, Edinburgh (BITE) and Eating Disorders Examination Questionnaire (EDE-Q), the Patient Health Questionnaire (PHQ-9) measure of depression; and the Generalized Anxiety Disorder (GAD-7) measure of anxiety. No difference was observed in the RMET scores between women with BN and HW. Both groups showed activation in brain regions specific to social cognition. During the task, no differences were shown between the groups in the BOLD signal (p < 0.05, familywise error corrected for multiple comparisons). However, there was a tendency of more robust activation in the right angular gyrus, ventral diencephalon, thalamus proper, temporal pole, and middle temporal gyrus in BN (p < 0.001, uncorrected for multiple comparisons). Moreover, HW showed a positive correlation between RMET scores and the activation of two regions: medial prefrontal cortex (mPFC) and anterior cingulate cortex (ACC); however, no significant correlation was observed in women with BN. While activation in the mPFC and ACC positively correlated to the RMET scores in HW, no correlation was observed in BN patients. Therefore, women with BN might display modulated neural processing when thinking of others’ mental states. Further examination is needed to investigate neural processing in BN patients to better understand their social cognition abilities. UMIN, UMIN000010220. Registered 13 March 2013, https://rctportal.niph.go.jp/s/detail/um?trial_id=UMIN000010220
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来源期刊
CiteScore
3.60
自引率
0.00%
发文量
23
审稿时长
18 weeks
期刊介绍: BioPsychoSocial Medicine is an open access, peer-reviewed online journal that encompasses all aspects of the interrelationships between the biological, psychological, social, and behavioral factors of health and illness. BioPsychoSocial Medicine is the official journal of the Japanese Society of Psychosomatic Medicine, and publishes research on psychosomatic disorders and diseases that are characterized by objective organic changes and/or functional changes that could be induced, progressed, aggravated, or exacerbated by psychological, social, and/or behavioral factors and their associated psychosomatic treatments.
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