根管治疗学的革命：治疗根尖封闭和根尖病变的成熟牙齿的创新方法：两个病例的报告

IF 3.5 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of endodontics Pub Date : 2024-05-01 DOI:10.1016/j.joen.2024.02.012

Claudia Brizuela PhD , Gastón Meza DDS , Maroun Khoury PhD

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引用次数: 0

摘要

导言现代组织工程学策略阐明了再生牙髓治疗（RET）作为治疗成熟牙齿替代方法的潜力。方法我们报告了两个病例，在两个牙髓坏死和根尖牙周炎的成熟牙齿中使用了基于细胞的再生牙髓治疗（CB-RET），在基于贫血小板血浆（PPP）的支架中包裹异体脐带间充质干细胞（UC-MSCs）。结果经过 5 年的随访，两个病例的愈合反应均令人满意，并有牙髓再生的迹象。结论这是第一项报告异体 CB-RET 延长 5 年随访成功的研究。该报告为具有挑战性的牙髓治疗方案提供了一种创新且可持续的解决方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Revolutionizing Endodontics: Innovative Approaches for Treating Mature Teeth With Closed Apices and Apical Lesions: A Report of Two Cases

Introduction

Modern tissue engineering strategies have elucidated the potential of regenerative endodontic treatment (RET) as an alternative for treating mature teeth.

Methods

Here, we report two cases in which cell-based RET (CB-RET) using encapsulated allogeneic umbilical cord mesenchymal stem cells (UC-MSCs) in a platelet-poor plasma (PPP)-based scaffold was used in two mature teeth with pulp necrosis and apical periodontitis.

Results

After 5 years of follow-up, the healing response was satisfactory in both cases, with evidence of pulp revitalization.

Conclusions

This is the first study to report the success of an extended, 5-year follow-up for allogeneic CB-RET. This report presents an innovative and sustainable solution to challenging endodontic scenarios.

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来源期刊

Journal of endodontics 医学-牙科与口腔外科

CiteScore

8.80

自引率

9.50%

发文量

224

审稿时长

42 days

期刊介绍： The Journal of Endodontics, the official journal of the American Association of Endodontists, publishes scientific articles, case reports and comparison studies evaluating materials and methods of pulp conservation and endodontic treatment. Endodontists and general dentists can learn about new concepts in root canal treatment and the latest advances in techniques and instrumentation in the one journal that helps them keep pace with rapid changes in this field.