Jie Yu, Qiang Zhao, Ting Xiao, Han-Wu Liu, Xi-Liang Chen, Jia He, Ting-Ting Yan
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Fabrication and characterization of biomimetic injectable HA/GT-OSA composites for bone regeneration
To address the issue of limited bone repair efficacy, a novel biomimetic HA/GT-OSA composite was synthesized through crosslinking gelatin (GT) with oxidized sodium alginate (OSA) for encapsulating hydroxyapatite (HA). The physicochemical properties of the composite were assessed using SEM, XRD, and FT-IR analyses. The biodegradability and biocompatibility of the HA/GT-OSA were confirmed via simulated body fluid (SBF) degradation testing and toxicity evaluation. Moreover, the HA/GT-OSA composites showed excellent bone regeneration performance in the SD rats intracranial bone repair, highlighting their immense potential for treating irregular bone defects and facilitating minimally invasive surgical implantation.
期刊介绍：
MRS Communications is a full-color, high-impact journal focused on rapid publication of completed research with broad appeal to the materials community. MRS Communications offers a rapid but rigorous peer-review process and time to publication. Leveraging its access to the far-reaching technical expertise of MRS members and leading materials researchers from around the world, the journal boasts an experienced and highly respected board of principal editors and reviewers.
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