Dircéia Aparecida da Costa Custódio , Carine Rodrigues Pereira , Maysa Serpa Gonçalves , Anna Cecília Trolesi Reis Borges Costa , Pedro Felipe Rodrigues de Oliveira , Bruna Henrique Pinto da Silva , Giovanna Botelho Carneiro , Fernanda Morcatti Coura , Andrey Pereira Lage , Marcos Bryan Heinemann , Geraldo M.árcio da Costa , Elaine Maria Seles Dorneles
{"title":"抗菌药耐药性以及从小牛体内分离的致病性大肠埃希氏菌对公众和动物健康造成的风险","authors":"Dircéia Aparecida da Costa Custódio , Carine Rodrigues Pereira , Maysa Serpa Gonçalves , Anna Cecília Trolesi Reis Borges Costa , Pedro Felipe Rodrigues de Oliveira , Bruna Henrique Pinto da Silva , Giovanna Botelho Carneiro , Fernanda Morcatti Coura , Andrey Pereira Lage , Marcos Bryan Heinemann , Geraldo M.árcio da Costa , Elaine Maria Seles Dorneles","doi":"10.1016/j.cimid.2024.102149","DOIUrl":null,"url":null,"abstract":"<div><p>We aimed to determine the antimicrobial susceptibility profile of pathogenic <em>Escherichia coli</em> strains isolated from fecal samples of calves and buffalo calves (2008–2013), in Minas Gerais, Brazil, as well as the frequency of O157 gene and strains carrying extended-spectrum beta-lactamases (ESBL) and mobile colistin resistance (<em>mcr</em>) genes. <em>E. coli</em> strains (n=518) were tested for susceptibility against ten antimicrobials. Tetracycline was the antimicrobial with the highest resistance rate (382/518), followed by ampicillin (321/518), sulfamethoxazole/trimethoprim (312/518), chloramphenicol (192/518), gentamicin (126/518), ciprofloxacin (148/518), cefazolin (89/518), colistin (54/518) and cefoxitin (34/518). Multidrug resistance (MDR) was observed in 381/518 isolates. No strain harbored <em>mcr</em> or O157 genes<em>,</em> whereas 19/99 were ESBL positive. The most prevalent pathotype and phylogroup were STEC and B1, respectively. Age, EHEC pathotype and resistance to aminoglycoside and cephem were significantly associated with MDR in the multivariate model. Overall, <em>E. coli</em> strains showed high rates of resistance to penicillin, tetracyclines and folate inhibitors, in addition to an alarming rate of MDR and ESBL-producing strains.</p></div>","PeriodicalId":50999,"journal":{"name":"Comparative Immunology Microbiology and Infectious Diseases","volume":"107 ","pages":"Article 102149"},"PeriodicalIF":2.0000,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antimicrobial resistance and public and animal health risks associated with pathogenic Escherichia coli isolated from calves\",\"authors\":\"Dircéia Aparecida da Costa Custódio , Carine Rodrigues Pereira , Maysa Serpa Gonçalves , Anna Cecília Trolesi Reis Borges Costa , Pedro Felipe Rodrigues de Oliveira , Bruna Henrique Pinto da Silva , Giovanna Botelho Carneiro , Fernanda Morcatti Coura , Andrey Pereira Lage , Marcos Bryan Heinemann , Geraldo M.árcio da Costa , Elaine Maria Seles Dorneles\",\"doi\":\"10.1016/j.cimid.2024.102149\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>We aimed to determine the antimicrobial susceptibility profile of pathogenic <em>Escherichia coli</em> strains isolated from fecal samples of calves and buffalo calves (2008–2013), in Minas Gerais, Brazil, as well as the frequency of O157 gene and strains carrying extended-spectrum beta-lactamases (ESBL) and mobile colistin resistance (<em>mcr</em>) genes. <em>E. coli</em> strains (n=518) were tested for susceptibility against ten antimicrobials. Tetracycline was the antimicrobial with the highest resistance rate (382/518), followed by ampicillin (321/518), sulfamethoxazole/trimethoprim (312/518), chloramphenicol (192/518), gentamicin (126/518), ciprofloxacin (148/518), cefazolin (89/518), colistin (54/518) and cefoxitin (34/518). Multidrug resistance (MDR) was observed in 381/518 isolates. No strain harbored <em>mcr</em> or O157 genes<em>,</em> whereas 19/99 were ESBL positive. The most prevalent pathotype and phylogroup were STEC and B1, respectively. Age, EHEC pathotype and resistance to aminoglycoside and cephem were significantly associated with MDR in the multivariate model. Overall, <em>E. coli</em> strains showed high rates of resistance to penicillin, tetracyclines and folate inhibitors, in addition to an alarming rate of MDR and ESBL-producing strains.</p></div>\",\"PeriodicalId\":50999,\"journal\":{\"name\":\"Comparative Immunology Microbiology and Infectious Diseases\",\"volume\":\"107 \",\"pages\":\"Article 102149\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2024-02-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comparative Immunology Microbiology and Infectious Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0147957124000262\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comparative Immunology Microbiology and Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0147957124000262","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
Antimicrobial resistance and public and animal health risks associated with pathogenic Escherichia coli isolated from calves
We aimed to determine the antimicrobial susceptibility profile of pathogenic Escherichia coli strains isolated from fecal samples of calves and buffalo calves (2008–2013), in Minas Gerais, Brazil, as well as the frequency of O157 gene and strains carrying extended-spectrum beta-lactamases (ESBL) and mobile colistin resistance (mcr) genes. E. coli strains (n=518) were tested for susceptibility against ten antimicrobials. Tetracycline was the antimicrobial with the highest resistance rate (382/518), followed by ampicillin (321/518), sulfamethoxazole/trimethoprim (312/518), chloramphenicol (192/518), gentamicin (126/518), ciprofloxacin (148/518), cefazolin (89/518), colistin (54/518) and cefoxitin (34/518). Multidrug resistance (MDR) was observed in 381/518 isolates. No strain harbored mcr or O157 genes, whereas 19/99 were ESBL positive. The most prevalent pathotype and phylogroup were STEC and B1, respectively. Age, EHEC pathotype and resistance to aminoglycoside and cephem were significantly associated with MDR in the multivariate model. Overall, E. coli strains showed high rates of resistance to penicillin, tetracyclines and folate inhibitors, in addition to an alarming rate of MDR and ESBL-producing strains.
期刊介绍：
Comparative Immunology, Microbiology & Infectious Diseases aims to respond to the concept of "One Medicine" and to provide a venue for scientific exchange. Based on the concept of "Comparative Medicine" interdisciplinary cooperation between specialists in human and animal medicine is of mutual interest and benefit. Therefore, there is need to combine the respective interest of physicians, veterinarians and other health professionals for comparative studies relevant to either human or animal medicine .
The journal is open to subjects of common interest related to the immunology, immunopathology, microbiology, parasitology and epidemiology of human and animal infectious diseases, especially zoonotic infections, and animal models of human infectious diseases. The role of environmental factors in disease emergence is emphasized. CIMID is mainly focusing on applied veterinary and human medicine rather than on fundamental experimental research.
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