更年期激素疗法能改善抑郁症状吗?更年期专科门诊的研究结果。

IF 2.8 3区 医学 Q1 OBSTETRICS & GYNECOLOGY
Rahavi Gnanasegar, Wendy Wolfman, Leticia Hernandez Galan, Amie Cullimore, Alison K Shea
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引用次数: 0

摘要

目的:抑郁症状常见于围绝经期和绝经后早期。虽然更年期激素疗法(MHT)被认为是治疗血管运动症状最有效的方法,但其对情绪相关症状的影响却不太确定。本研究旨在评估在加拿大一家更年期专科门诊就医的妇女在开始接受 MHT 治疗后抑郁症状的间歇性变化:本研究邀请了在安大略省汉密尔顿市圣约瑟夫医疗保健更年期诊所就诊的妇女和女性患者参加。参与者(n = 170)在初次就诊时填写了一份自我报告问卷,其中包括病史以及有关困扰症状的验证工具。在 3 至 12 个月后的随访中,我们使用相同的验证工具对其进行了简化。我们试图在控制相关人口统计学变量(吸烟、教育水平、年龄)的同时,根据所使用的治疗类型和 MHT 剂量来检测流行病学研究中心抑郁量表的间隔变化:结果:寻求更年期专科治疗的患者中,抑郁症状的比例很高(62%)。无论是单独使用还是在服用抗抑郁药物的同时使用MHT,抑郁症状都会得到明显改善(P < 0.001)。年龄较小、教育程度较低和吸烟都与抑郁评分较高有关:本研究支持使用MHT来改善寻求更年期专科治疗的患者的抑郁症状。对开始治疗时机的进一步研究可能有助于采用个性化治疗方法,改善围绝经期和绝经后妇女的生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Does menopause hormone therapy improve symptoms of depression? Findings from a specialized menopause clinic.

Objective: Depressive symptoms are commonly reported during the perimenopause and in the early postmenopausal years. Although menopausal hormone therapy (MHT) is considered the most effective treatment option for vasomotor symptoms, its effect on mood-related symptoms is less established. This study aims to assess interval change in depressive symptoms after initiation of MHT treatment in women seeking care at a Canadian specialized menopause clinic.

Methods: Women and female-presenting people attending the St. Joseph's Healthcare Menopause Clinic in Hamilton, Ontario, were invited to participate in this study. Participants (n = 170) completed a self-report questionnaire, which included their medical history as well as validated tools for bothersome symptoms at their initial visit. A shortened version was administered at the follow-up visit 3 to 12 months later with the same validated tools. We sought to examine interval changes on the Center for Epidemiological Studies Depression Scale based on type of treatment used and MHT dose, while controlling for relevant demographic variables (smoking, education level, age).

Results: There was a high rate of depressive symptoms in those seeking specialized menopause care (62%). MHT use was associated with significantly improved depressive symptoms, both alone and in addition to an antidepressant medication ( P < 0.001). Younger age, lower education attainment, and smoking were all associated with higher depression scores.

Conclusion: This study supports the use of MHT to improve depressive symptoms experienced by those seeking specialized menopause care. Further investigation into timing of treatment initiation may facilitate a personalized treatment approach to improve quality of life of women in the peri- and postmenopausal years.

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来源期刊
CiteScore
5.40
自引率
7.40%
发文量
330
审稿时长
3-8 weeks
期刊介绍: ​Menopause, published monthly, provides a forum for new research, applied basic science, and clinical guidelines on all aspects of menopause. The scope and usefulness of the journal extend beyond gynecology, encompassing many varied biomedical areas, including internal medicine, family practice, medical subspecialties such as cardiology and geriatrics, epidemiology, pathology, sociology, psychology, anthropology, and pharmacology. This forum is essential to help integrate these areas, highlight needs for future research, and enhance health care.
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