根除幽门螺旋杆菌的纳米药物：最新进展、挑战和未来展望。

IF 2.5 4区生物学 Q3 MICROBIOLOGY

Future microbiology Pub Date : 2024-03-01 Epub Date: 2024-02-21 DOI:10.2217/fmb-2023-0189

Aakriti Garg, Sonali Karhana, Mohd A Khan

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引用次数: 0

摘要

幽门螺旋杆菌感染与胃炎、溃疡和胃癌有关。纳米医学提供了一种前景广阔的解决方案，即利用纳米颗粒精确给药，解决抗生素耐药性和给药问题。脂质体和纳米颗粒等纳米载体可提高药物的稳定性和流通性，并通过胃黏膜的特性靶向感染部位。面临的挑战包括生物相容性、稳定性、可扩展性和个性化疗法。尽管障碍重重，但纳米医学在重塑幽门螺杆菌根除方法方面的潜力巨大，本综述将重点介绍基于纳米医学策略的益处、局限性和未来前景。

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Nanomedicine for the eradication of Helicobacter pylori: recent advances, challenges and future perspective.

Helicobacter pylori infection is linked to gastritis, ulcers and gastric cancer. Nanomedicine offers a promising solution by utilizing nanoparticles for precise drug delivery, countering antibiotic resistance and delivery issues. Nanocarriers such as liposomes and nanoparticles enhance drug stability and circulation, targeting infection sites through gastric mucosa characteristics. Challenges include biocompatibility, stability, scalability and personalized therapies. Despite obstacles, nanomedicine's potential for reshaping H. pylori eradication is significant and showcased in this review focusing on benefits, limitations and future prospects of nanomedicine-based strategies.

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来源期刊

Future microbiology 生物-微生物学

CiteScore

4.90

自引率

3.20%

发文量

134

审稿时长

6-12 weeks

期刊介绍： Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.