M E Galagan, E V Oranovskaia, P I Mordvintsev, O S Medvedev, A F Vanin
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[Hypotensive effect of dinitrosyl iron complexes in experiments on waking animals].
Changes in arterial pressure evoked by dinitrosyl iron complexes (DNIC) were studied in conscious normotensive (Wistar) and spontaneously hypertensive (SHR) rats. Doses from 1 to 10 mcM/kg of DNIC evoked dose-dependent decrease in blood pressure for two hours. SHR rats were more sensitive to the effect of the drug than normotensive Wistar rats. Long-lasting effects of the drug depended on the NO-stores, which were DNIC with paired RS-(-)groups of proteins. These complexes measured with EPR method were formed as a result of Fe(NO)2 groups transfer from injected low molecular weight DNIC to protein RS-(-)groups.
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