Advances in Neuromodulation for Older Adults with Mood and Neurocognitive Disorders

Older adults with Alzheimer's Disease and Related Dementias (ADRD) and those with high risk conditions such as major depressive disorder (D) or mild cognitive impairment (MCI) are growing in numbers. Interventions to treat these conditions early and to prevent cognitive decline and ADRD are highly needed. This session will present results from new studies examining neuromodulation alone or in combination with other modalities in these populations. Dr. Linda Mah will present on deep Transcranial Magnetic Stimulation (dTMS) for older adults with treatment-resistant D or memory concerns. Dr. Krista Lanctôt will present preliminary results from a trial combining transcranial Direct Current Stimulation (tDCS) with exercise for older adults with early AD or MCI. Last, Dr. Tarek Rajji will present the results of a large 7-year randomized controlled trial (Preventing Alzheimer's dementia with cognitive remediation plus transcranial direct current stimulation in mild cognitive impairment and depression: PACt-) that aimed to prevent cognitive decline and dementia among older adults with MCI or remitted D with or without MCI using the combination of tDCS and cognitive remediation. Overall, this panel will present novel unpublished data across various neuromodulation trials of different designs with various outcomes relevant to preventing cognitive decline and ADRD.